典型文献
TRIM25 activates AKT/mTOR by inhibiting PTEN via K63-linked polyubiquitination in non-small cell lung cancer
文献摘要：
The PTEN/AKT/mTOR signaling pathway is frequently dysregulated in non-small cell lung cancer(NSCLC),but the mechanisms are not well-understood.The present study found that the ubiquitin ligase TRIM25 is highly expressed in NSCLC tissues and promotes NSCLC cell survival and tumor growth.Mechanistic studies revealed that TRIM25 binds to PTEN and mediates its K63-linked ubiquitination at K266.This modification prevents the plasma membrane translocation of PTEN and reduces its phosphatase activity therefore accumulating PI(3,4,5)P3.TRIM25 thus activates the AKT/mTOR signaling.Moreover,we found that the antibacterial nitroxoline can activate PTEN by reducing its K63-linked polyubiquitination and sensitizes NSCLC to cisplatin-induced apoptosis.This study thus identified a novel modulation on the PTEN signaling pathway by TRIM25 and provides a potential target for NSCLC treatment.
文献关键词：
中图分类号：
作者姓名：
Yuan-ming He;Xiu-min Zhou;Shuo-yi Jiang;Zu-bin Zhang;Bi-yin Cao;Jin-bao Liu;Yuan-ying Zeng;Jun Zhao;Xin-liang Mao
作者机构：
Guangdong Key Laboratory of Protein Modification and Degradation,School of Basic Medical Sciences,Guangzhou Medical University,Guangzhou 511436,China;Department of Pharmacology,College of Pharmaceutical Sciences,Soochow University,Suzhou 215123,China;Department of Oncology,The First Affiliated Hospital of Soochow University,Suzhou 215106,China;Department of Oncology,Suzhou Municipal Hospital,Suzhou 215100,China;Department of Thoracic Surgery,The First Affiliated Hospital of Soochow University,Suzhou 215106,China
文献出处：
引用格式：
[1]Yuan-ming He;Xiu-min Zhou;Shuo-yi Jiang;Zu-bin Zhang;Bi-yin Cao;Jin-bao Liu;Yuan-ying Zeng;Jun Zhao;Xin-liang Mao-.TRIM25 activates AKT/mTOR by inhibiting PTEN via K63-linked polyubiquitination in non-small cell lung cancer)[J].中国药理学报（英文版）,2022(03):681-691
A类：
polyubiquitination,K266,nitroxoline
B类：
TRIM25,activates,AKT,mTOR,by,inhibiting,PTEN,via,K63,linked,small,cell,lung,cancer,signaling,pathway,frequently,dysregulated,NSCLC,but,mechanisms,are,not,well,understood,present,study,found,that,ligase,highly,expressed,tissues,promotes,survival,tumor,growth,Mechanistic,studies,revealed,binds,mediates,its,This,modification,prevents,plasma,membrane,translocation,reduces,phosphatase,activity,therefore,accumulating,P3,thus,Moreover,antibacterial,reducing,sensitizes,cisplatin,induced,apoptosis,identified,novel,modulation,provides,potential,target,treatment
AB值：
0.508192
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
