典型文献
Five Rutaceae family ethanol extracts alleviate H2O2 and LPS-in-duced inflammation via NF-кB and JAK-STAT3 pathway in HaCaT cells
文献摘要：
This study was designed to investigate the effects of five Rutaceae family ethanol extracts(FRFEE):Citrus medica Linn(CML),Citrus aurantium L.Cv.Daidai(CAD),Citrus medica Linn.var.sarcodactylis(Noot.)Swingle(CMS),Citrus sinensis L.Osbeck(CSO)and Zanthoxylum bungeanum Maxim(ZBM)on retarding the progression of H202 and LPS-induced HaCaT cells.Cell inflammatory injury model was established by H202 and LPS.The alleviative effects of FRFEE were evaluated by detecting the activ-ity of superoxide dismutase(SOD),glutathione(GSH)and the generation of reactive oxygen species(ROS).The inflammatory signal-ing pathways of NF-κB and JAK-STAT3 were detected by Western blotting,the mRNA expression levels of inflammatory factors and skin barrier factors were detected by RT-PCR.50％ethanol extracts of five medicinal and food homologous herbs of Rutaceae family showed different levels of anti-oxidant and anti-inflammatory activities.The FRFEE effectively improved SOD and GSH content and decreased ROS levels.Meanwhile,FRFEE strongly suppressed two inflammatory signaling pathways NF-κB and JAK-STAT3.The RT-PCR examination of inflammatory factors and skin barrier factor revealed significant anti-inflammatory effects of FRFEE.It was worth noting that among the five extracts,Zanthoxylum bungeanum Maxim extract had the best anti-inflammatory and anti-oxidation effects.In addition,it could strongly inhibit the expression of psoriasis factor CCL20.In summary,these results suggested that Zanthoxylum bungeanum Maxim extract could be used as an anti-psoriatic agent in the treatment of psoriasis among FRFEE.
文献关键词：
中图分类号：
作者姓名：
HONG Mengsa;XIAO Kun;LIN Pei;LIN Jun
作者机构：
School of Life sciences and Health Engineering,Jiangnan University,Wuxi 214122,China
文献出处：
引用格式：
[1]HONG Mengsa;XIAO Kun;LIN Pei;LIN Jun-.Five Rutaceae family ethanol extracts alleviate H2O2 and LPS-in-duced inflammation via NF-кB and JAK-STAT3 pathway in HaCaT cells)[J].中国天然药物,2022(12):937-947
A类：
FRFEE,Daidai,sarcodactylis,Noot,ZBM,alleviative
B类：
Five,Rutaceae,family,ethanol,extracts,alleviate,H2O2,LPS,inflammation,JAK,STAT3,HaCaT,cells,This,study,was,designed,investigate,effects,five,Citrus,medica,Linn,CML,aurantium,Cv,CAD,var,Swingle,CMS,sinensis,Osbeck,CSO,Zanthoxylum,bungeanum,Maxim,retarding,progression,H202,induced,Cell,inflammatory,injury,model,established,by,were,evaluated,detecting,ity,superoxide,dismutase,glutathione,GSH,generation,reactive,oxygen,species,ROS,pathways,detected,blotting,expression,levels,factors,skin,barrier,medicinal,food,homologous,herbs,showed,different,oxidant,activities,effectively,improved,content,decreased,Meanwhile,strongly,suppressed,two,signaling,examination,revealed,significant,It,worth,noting,that,among,had,best,oxidation,In,addition,could,inhibit,psoriasis,CCL20,summary,these,results,suggested,used,psoriatic,agent,treatment
AB值：
0.459662
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
