典型文献
A systematic review on the safety of Psoraleae Fructus:potential risks,toxic characteristics,underlying mechanisms and detoxification methods
文献摘要：
Psoraleae Fructus(PF)is an important traditional herbal medicine with a long history of clinical application.It is widely used to treat various diseases,such as osteoporosis,leucoderma and diarrhea.As a traditional nontoxic herb,it has aroused worldwide concern about the potential risks due to increasing adverse reaction events.This article reviews the botany,ancient records of medical uses,adverse reactions,toxicological research advance and detoxification methods of PF.According to clinical studies,liv-er injury is the most predominant in PF-related adverse reactions.The underlying mechanisms include bile acid metabolism and trans-port disorders,oxidative stress,mitochondrial damage,inhibition of liver cell regeneration and inflammatory reactions.Furthermore,the potential toxins of PF are summarized.Traditional methods of processing and compatibility will provide reference for reducing the toxicity of PF,which requires further research.In sum,this work systematically summarizes the reserach progress on the safety of PF,which will provide comprehensive insights into the toxicity of PF and facilitate its safe use and future development.
文献关键词：
中图分类号：
作者姓名：
SHI Zhuo;GAO Jing;PAN Jinchao;ZHANG Zuqi;ZHANG Guangchen;WANG Yuguang;GAO Yue
作者机构：
Department of Pharmaceutical Sciences,Beijing Institute of Radiation Medicine,Beijing 100850,China
文献出处：
引用格式：
[1]SHI Zhuo;GAO Jing;PAN Jinchao;ZHANG Zuqi;ZHANG Guangchen;WANG Yuguang;GAO Yue-.A systematic review on the safety of Psoraleae Fructus:potential risks,toxic characteristics,underlying mechanisms and detoxification methods)[J].中国天然药物,2022(11):805-813
A类：
Psoraleae,leucoderma,botany,reserach
B类：
safety,Fructus,potential,risks,characteristics,underlying,mechanisms,detoxification,methods,PF,important,traditional,herbal,medicine,long,history,clinical,application,It,widely,treat,various,diseases,such,osteoporosis,diarrhea,nontoxic,has,aroused,worldwide,concern,about,due,increasing,adverse,events,This,article,reviews,ancient,records,medical,uses,reactions,toxicological,research,advance,According,studies,injury,most,predominant,related,include,bile,acid,metabolism,trans,disorders,oxidative,stress,mitochondrial,damage,inhibition,liver,cell,regeneration,inflammatory,Furthermore,toxins,are,summarized,Traditional,processing,compatibility,will,provide,reference,reducing,toxicity,which,requires,further,In,this,work,systematically,summarizes,progress,comprehensive,insights,into,facilitate,its,future,development
AB值：
0.573405
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