典型文献
The extract of Celtis choseniana Nakai alleviates testosterone-in-duced benign prostatic hyperplasia through inhibiting 5 a reductase type 2 and the Akt/NF-κB/AR pathway
文献摘要：
Benign prostatic hyperplasia(BPH)is a chronic male disease characterized by the enlarged prostate.Celtis choseniana Nakai(C.choseniana)is medicinally used to alleviate pain,gastric disease,and lung abscess.In this study,the effect of C.choseniana extract on BPH was investigated using testosterone-induced rats.Sprague Dawley rats were divided into five groups:control,BPH(testosterone 5 mg·kg-1),Fina(finasteride 2 mg·kg-1),and C.choseniana(50 and 100 mg·kg-1).After four weeks of TP treatment with finasteride or C.choseniana,prostate weights and DHT levels were measured.In addition,the prostates were histopathologically ex-amined and measured for protein kinase B(Akt)/nuclear factor-κB(NF-κB)/AR signaling,proliferation,apoptosis,and autophagy.Pro-state weight and epithelial thickness were reduced in the C.choseniana groups compared with that in the BPH group.The extract of C.choseniana acted as a 5a reductase inhibitor,reducing DHT levels in the prostate.Furthermore,the extract of C.choseniana blocked the activation of p-Akt,nuclear NF-κB activation and reduced the expression of AR and PSA compared with BPH.Moreover,the ex-pression of Bax,PARP-1,and p53 increased,while the expression of bcl-2 decreased.The present study demonstrated that C.choseni-ana extract alleviated testosterone-induced BPH by suppressing 5α reductase and Akt/NF-κB activation,reducing AR signaling and in-ducing apoptosis and autophagy in the prostate.These results suggested that C.choseniana probably contain potential herbal agents to alleviate BPH.
文献关键词：
中图分类号：
作者姓名：
HONG Geum-Lan;KIM Tae-Won;LEE Hui-Ju;KIM Yae-Ji;KIM Kyung-Hyun;JUNG Ju-Young
作者机构：
Department of Veterinary Medicine&Institute of Veterinary Science,Chungnam National University,Daejeon 34134,Republic of Korea
文献出处：
引用格式：
[1]HONG Geum-Lan;KIM Tae-Won;LEE Hui-Ju;KIM Yae-Ji;KIM Kyung-Hyun;JUNG Ju-Young-.The extract of Celtis choseniana Nakai alleviates testosterone-in-duced benign prostatic hyperplasia through inhibiting 5 a reductase type 2 and the Akt/NF-κB/AR pathway)[J].中国天然药物,2022(07):518-526
A类：
choseniana,Fina,finasteride,prostates,amined,choseni
B类：
extract,Celtis,Nakai,alleviates,testosterone,benign,prostatic,hyperplasia,through,inhibiting,reductase,type,Akt,pathway,Benign,BPH,chronic,male,disease,characterized,by,enlarged,medicinally,used,pain,gastric,lung,abscess,In,this,study,effect,was,investigated,using,induced,rats,Sprague,Dawley,were,divided,into,five,groups,control,After,four,weeks,TP,treatment,weights,DHT,levels,measured,addition,histopathologically,protein,kinase,nuclear,signaling,proliferation,apoptosis,autophagy,Pro,epithelial,thickness,reduced,compared,that,acted,5a,inhibitor,reducing,Furthermore,blocked,activation,expression,PSA,Moreover,Bax,PARP,p53,increased,while,bcl,decreased,present,demonstrated,alleviated,suppressing,These,results,suggested,probably,contain,potential,herbal,agents
AB值：
0.428956
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