Central nervous system(CNS)injuries,includ-ing stroke,traumatic brain injury,and spinal cord injury,are leading causes of long-term disability.It is estimated that more than half of the survivors of severe unilateral injury are unable to use the denervated limb.Previous studies have focused on neuroprotective interventions in the affected hemisphere to limit brain lesions and neurorepair measures to promote recovery.However,the ability to increase plastic-ity in the injured brain is restricted and difficult to improve.Therefore,over several decades,researchers have been prompted to enhance the compensation by the unaffected hemisphere.Animal experiments have revealed that regrowth of ipsilateral descending fibers from the unaffected hemisphere to denervated motor neurons plays a significant role in the restoration of motor function.In addition,several clinical treatments have been designed to restore ipsilateral motor control,including brain stimulation,nerve transfer surgery,and brain-computer interface systems.Here,we comprehensively review the neural mechanisms as well as translational applications of ipsilateral motor control upon rehabilitation after CNS injuries.

Zhengrun Gao;Zhen Pang;Yiming Chen;Gaowei Lei;Shuai Zhu;Guotao Li;Yundong Shen;Wendong Xu

Department of Hand Surgery,Huashan Hospital,Fudan University,Shanghai 200040,China;The National Clinical Research Center for Aging and Medicine,Fudan University,Shanghai 200040,China;Co-innovation Center of Neuroregeneration,Nantong University,Nantong 226000,China;Department of Hand and Upper Extremity Surgery,Jing'an District Central Hospital,Fudan University,Shanghai 200040,China;Institutes of Brain Science,Fudan University,Shanghai 200040,China;State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Fudan University,Shanghai 200040,China;Research Unit of Synergistic Reconstruction of Upper and Lower Limbs after Brain Injury,Chinese Academy of Medical Sciences,Shanghai 200400,China

神经科学通报（英文版）

[1]Zhengrun Gao;Zhen Pang;Yiming Chen;Gaowei Lei;Shuai Zhu;Guotao Li;Yundong Shen;Wendong Xu-.Restoring After Central Nervous System Injuries:Neural Mechanisms and Translational Applications of Motor Recovery)[J].神经科学通报（英文版）,2022(12):1569-1587

denervated,neurorepair

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