典型文献
Sexual Dimorphism of Inputs to the Lateral Habenula in Mice
文献摘要：
The lateral habenula(LHb),which is a critical neuroanatomical hub and a regulator of midbrain monoaminergic centers,is activated by events resulting in negative valence and contributes to the expression of both appetitive and aversive behaviors.However,whole-brain cell-type-specific monosynaptic inputs to the LHb in both sexes remain incompletely elucidated.In this study,we used viral tracing combined with in situ hybridization targeting vesicular glutamate transporter 2(vGlut2)and glutamic acid decarboxylase 2(Gad2)to generate a comprehensive whole-brain atlas of inputs to glutamatergic and y-aminobutyric acid(GABA)ergic neurons in the LHb.We found＞30 ipsilateral and contralateral brain regions that projected to the LHb.Of these,there were significantly more monosynaptic LHb-projecting neurons from the lateral septum,anterior hypothalamus,dorsomedial hypothalamus,and ventromedial hypothalamus in females than in males.More interestingly,we found a stronger GABAergic projection from the medial septum to the LHb in males than in females.Our results reveal a comprehen-sive connectivity atlas of glutamatergic and GABAergic inputs to the LHb in both sexes,which may facilitate a better understanding of sexual dimorphism in physiological and pathological brain functions.
文献关键词：
中图分类号：
作者姓名：
Xue Liu;Hongren Huang;Yulin Zhang;Liping Wang;Feng Wang
作者机构：
Shenzhen Key Lab of Neuropsychiatric Modulation,Guang-dong Provincial Key Laboratory of Brain Connectome and Behavior,CAS Key Laboratory of Brain Connectome and Manipulation,the Brain Cognition and Brain Disease Insti-tute,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences;Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen 518055,China
文献出处：
引用格式：
[1]Xue Liu;Hongren Huang;Yulin Zhang;Liping Wang;Feng Wang-.Sexual Dimorphism of Inputs to the Lateral Habenula in Mice)[J].神经科学通报（英文版）,2022(12):1439-1456
A类：
Dimorphism,Habenula,habenula,LHb,monoaminergic,monosynaptic,vGlut2,Gad2,ergic,ventromedial
B类：
Sexual,Inputs,Lateral,Mice,which,critical,neuroanatomical,hub,regulator,midbrain,centers,activated,by,events,resulting,negative,valence,contributes,expression,both,appetitive,aversive,behaviors,However,whole,cell,type,specific,inputs,sexes,remain,incompletely,elucidated,this,study,used,viral,tracing,combined,situ,hybridization,targeting,vesicular,transporter,glutamic,acid,decarboxylase,generate,comprehensive,atlas,glutamatergic,aminobutyric,neurons,We,found,ipsilateral,contralateral,regions,that,projected,Of,these,there,were,significantly,more,projecting,from,septum,anterior,hypothalamus,dorsomedial,females,than,More,interestingly,stronger,GABAergic,projection,Our,results,reveal,connectivity,may,facilitate,better,understanding,sexual,dimorphism,physiological,pathological,functions
AB值：
0.522852
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
