典型文献
Factors Influencing Alzheimer's Disease Risk:Whether and How They are Related to the APOE Genotype
文献摘要：
Alzheimer's disease(AD)is the most prevalent neurodegenerative disease featuring progressive cognitive impairment.Although the etiology of late-onset AD remains unclear,the close association of AD with apolipoprotein E(APOE),a gene that mainly regulates lipid metabolism,has been firmly established and may shed light on the exploration of AD pathogenesis and therapy.However,various confounding factors interfere with the APOE-related AD risk,raising questions about our com-prehension of the clinical findings concerning APOE.In this review,we summarize the most debated factors interacting with the APOE genotype and AD pathogenesis,depict the extent to which these factors relate to APOE-dependent AD risk,and discuss the possible underlying mechanisms.
文献关键词：
中图分类号：
作者姓名：
Rong Zhang;Xiaojiao Xu;Hang Yu;Xiaolan Xu;Manli Wang;Weidong Le
作者机构：
Institute of Neurology,Sichuan Academy of Medical Sciences,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 611731,China
文献出处：
引用格式：
[1]Rong Zhang;Xiaojiao Xu;Hang Yu;Xiaolan Xu;Manli Wang;Weidong Le-.Factors Influencing Alzheimer's Disease Risk:Whether and How They are Related to the APOE Genotype)[J].神经科学通报（英文版）,2022(07):809-819
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0.658881
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