典型文献
Thermodynamic and kinetic mechanism of phase transformation of levofloxacin hydrochloride
文献摘要：
In this work,thermodynamic and kinetic factors that affect formation and phase transformation process of different solid forms of levofloxacin hydrochloride were investigated in detail.Dynamic vapor sorp-tion experiments(DVS)and varying temperature-powder X-ray diffraction(VT-PXRD)experiments were carried out to study moisture-dependent stability,thermal stability as well as the transformation process between Form Ⅰ and Form Ⅱ.Critical water activities of levofloxacin hydrochloride were determined in temperature range of 5.0-45.0℃.Raman spectroscopy was applied to in situ monitor the temperature-induced phase transformation and the hydration process of levofloxacin hydrochloride,and one possible mechanism consisting of multiple chemical equilibria was proposed to analyze the effect of thermody-namic and kinetic factors on the formation and transformation of different solid forms.Results show that the anhydrate,Form Ⅱ would transform to the monohydrate,Form Ⅰ more easily with the increasing water content.And the transition point moves toward higher water contents as the temperature increases.The results suggested that,except for thermodynamic factors,kinetic factors also play an essential role in controlling the solid forms of polymorphic compounds.
文献关键词：
中图分类号：
作者姓名：
Han Liu;Xiunan Zhang;Ting Wang;Xin Huang;Kui Chen;Na Wang;Shanshan Yu;Yuyuan Dong;Hongxun Hao
作者机构：
National Engineering Research Center for Industrial Crystallization Technology,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;Collaborative Innovation Center of Chemical Science and Engineering(Tianjin),Tianjin 300072,China;School of Chemical Engineering and Technology,Hainan University,Haikou 570208,China
文献出处：
引用格式：
[1]Han Liu;Xiunan Zhang;Ting Wang;Xin Huang;Kui Chen;Na Wang;Shanshan Yu;Yuyuan Dong;Hongxun Hao-.Thermodynamic and kinetic mechanism of phase transformation of levofloxacin hydrochloride)[J].颗粒学报（英文版）,2022(07):59-70
A类：
anhydrate
B类：
Thermodynamic,kinetic,mechanism,phase,transformation,levofloxacin,hydrochloride,In,this,work,thermodynamic,factors,that,affect,process,different,solid,forms,were,investigated,detail,Dynamic,vapor,sorp,experiments,DVS,varying,temperature,powder,ray,diffraction,VT,PXRD,carried,out,study,moisture,dependent,stability,thermal,well,between,Form,Critical,water,activities,determined,range,Raman,spectroscopy,was,applied,situ,monitor,induced,hydration,one,possible,consisting,multiple,chemical,equilibria,proposed,analyze,effect,Results,show,would,monohydrate,more,easily,increasing,And,transition,point,moves,toward,higher,contents,increases,results,suggested,except,also,play,essential,role,controlling,polymorphic,compounds
AB值：
0.549568
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
