典型文献
Recent advances in platelet engineering for anti-cancer therapies
文献摘要：
Platelets contribute a major role in hemostasis by clumping and coagulation at the site of blood vessel injuries.In light of recent findings of a close relationship between platelets and immunological response,as well as interactions between platelets and cancer cells,novel engineering strategies have emerged for the integration of platelets or platelet membrane (PM) with anti-cancer therapeutics.In this review,we discuss several recent innovations that use platelets or their membranes to circumvent host immune responses and target tumor cells with high specificity to deliver a range of pharmacological,photother-mal,or immunologic agents for eradication of recalcitrant tumor cells.More specifically,we compare the relative advantages of using whole platelets versus single or hybrid PM to coat nanoparticle cargoes.These cargoes range from well-established anti-tumor apoptosis-inducing agents,to relatively new photother-mal agents that can induce a feedback cascade in which they induce vascular damage to the tumor which recruits more platelet-or membrane-encapsulated agents to induce further damage.We also discuss the use of engineered platelets to produce programmed cell death-inducing platelet derived microparticles.This review provides an overview and future directions for this promising platelet-based biomimetic approach to anti-cancer therapy.
文献关键词：
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作者姓名：
Yanlin Lv;Wei Wei;Guanghui Ma
作者机构：
State Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China;School of Chemical Engineering,University of Chinese Academy of Sciences,Beijing 100049,China
文献出处：
引用格式：
[1]Yanlin Lv;Wei Wei;Guanghui Ma-.Recent advances in platelet engineering for anti-cancer therapies)[J].颗粒学报（英文版）,2022(05):2-13
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