典型文献
Recent progress in the structural study of ion channels as insecticide targets
文献摘要：
Ion channels,many expressed in insect neural and muscular systems,have drawn huge attention as primary targets of insecticides.With the recent technical break-throughs in structural biology,especially in cryo-electron microscopy(cryo-EM),many new high-resolution structures of ion channel targets,apo or in complex with insecti-cides,have been solved,shedding light on the molecular mechanism of action of the in-secticides and resistance mutations.These structures also provide accurate templates for structure-based insecticide screening and rational design.This review summarizes the re-cent progress in the structural studies of 5 ion channel families:the ryanodine receptor(RyR),the nicotinic acetylcholine receptor(nAChR),the voltage-gated sodium channel(VGSC),the transient receptor potential(TRP)channel,and the ligand-gated chloride channel(LGCC).We address the selectivity of the channel-targeting insecticides by exam-ining the conservation of key coordinating residues revealed by the structures.The possi-ble resistance mechanisms are proposed based on the locations of the identified resistance mutations on the 3D structures of the target channels and their impacts on the binding of insecticides.Finally,we discuss how to develop"green"insecticides with a novel mode of action based on these high-resolution structures to overcome the resistance.
文献关键词：
中图分类号：
作者姓名：
Hadiatullah Hadiatullah;Yongliang Zhang;Arthur Samurkas;Yunxuan Xie;Rajamanikandan Sundarraj;Han Zuilhof;Jianjun Qiao;Zhiguang Yuchi
作者机构：
Tianjin Key Laboratory for Modem Drug Delivery&High-Efficiency,Collaborative Innovation Center of Chemical Science and Engineer-ing,School of Pharmaceutical Science and Technology,Tianjin University,Tianjin,China;Laboratory of Organic Chemistry,Wageningen University&Research,Wageningen,The Netherlands;Department of Environmental Science,Tianjin University,Tianjin,China;Key Laboratory of Systems Bioengineering(Ministry of Education),Tianjin University,Tianjin,China;Department of Molecular Pharmacology,Tianjin Medical University Cancer Institute&Hospital;National Clinical Research Center for Cancer;Key Laboratory of Cancer Prevention and Therapy,Tianjin;Tianjin's Clinical Research Center for Cancer,Tianjin,China
文献出处：
引用格式：
[1]Hadiatullah Hadiatullah;Yongliang Zhang;Arthur Samurkas;Yunxuan Xie;Rajamanikandan Sundarraj;Han Zuilhof;Jianjun Qiao;Zhiguang Yuchi-.Recent progress in the structural study of ion channels as insecticide targets)[J].中国昆虫科学（英文版）,2022(06):1522-1551
A类：
insecti,cides,secticides,LGCC,ining
B类：
Recent,progress,structural,study,channels,targets,Ion,many,expressed,neural,muscular,systems,have,drawn,huge,attention,primary,insecticides,With,recent,technical,break,throughs,biology,especially,cryo,electron,microscopy,EM,new,high,resolution,structures,apo,complex,been,solved,shedding,light,molecular,action,resistance,mutations,These,also,provide,accurate,templates,screening,rational,design,This,review,summarizes,studies,families,ryanodine,receptor,RyR,nicotinic,acetylcholine,nAChR,voltage,gated,sodium,VGSC,transient,potential,TRP,ligand,chloride,We,address,selectivity,targeting,by,exam,conservation,key,coordinating,residues,revealed,possi,ble,mechanisms,are,proposed,locations,identified,their,impacts,binding,Finally,we,discuss,how,develop,green,novel,mode,these,overcome
AB值：
0.550756
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