典型文献
CK1α upregulates the IFNAR1 expression to prompt the anti-HBV effect of type ⅠIFN in hepatoma carcinoma cells
文献摘要：
Casein kinase 1α(CK1α)mediates the phosphorylation and degradation of interferon-α/p receptor 1(IFN AR1)in response to viral infection.However,how CK1α regulates hepatitis B virus(HBV)replication and the anti-HBV effects of IFN-α are less reported.Here we show that CK1α can interact with IFNAR1 in hepatoma carcinoma cells and increased the abundance of IFNAR1 by reducing the ubiquitination levels in the presence of HBV.Furthermore,CK1α promotes the IFN-α triggered JAK-STAT signaling pathway and consequently enhances the antiviral effects of IFN-α against HBV replication.Our results collectively provide evidence that CK1α positively regulates the anti-HBV activity of IFN-α in hepatoma carcinoma cells,which would be a promising therapeutic target to improve the effectiveness of IFN-α therapy to cure CHB.
文献关键词：
中图分类号：
作者姓名：
Jing Xiong;Yanjun Jiang;Jinru Zhang;Yanmeng Chen;Yuan Hu
作者机构：
Key Laboratory of Molecular Biology on Infectious Diseases,Ministry of Education,Institute for Viral Hepatitis,Department of Infectious Diseases,Second Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China
文献出处：
引用格式：
[1]Jing Xiong;Yanjun Jiang;Jinru Zhang;Yanmeng Chen;Yuan Hu-.CK1α upregulates the IFNAR1 expression to prompt the anti-HBV effect of type ⅠIFN in hepatoma carcinoma cells)[J].中国病毒学,2022(06):894-903
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0.567836
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