典型文献
The humoral and cellular immune evasion of SARS-CoV-2 Omicron and sub-lineages
文献摘要：
The recently discovered SARS-CoV-2 variant Omicron(B.1.1.529)has rapidly become a global public health issue.The substantial mutations in the spike protein in this new variant have raised concerns about its ability to escape from pre-existing immunity established by natural infection or vaccination.In this review,we give a summary of current knowledge concerning the antibody evasion properties of Omicron and its subvariants(BA.2,BA.2.12.1,BA.4/5,and BA.2.75)from therapeutic monoclonal antibodies and the sera of SARS-CoV-2 vaccine recipients or convalescent patients.We also summarize whether vaccine-induced cellular immunity(memory B cell and T cell response)can recognize Omicron specifically.In brief,the Omicron variants demonstrated remarkable antibody evasion,with even more striking antibody escape seen in the Omicron BA.4 and BA.5 sub-lineages.Luckily,the third booster vaccine dose significantly increased the neutralizing antibodies titers,and the vaccine-induced cellular response remains conserved and provides second-line defense against the Omicron.
文献关键词：
中图分类号：
作者姓名：
Tiandan Xiang;Junzhong Wang;Xin Zheng
作者机构：
Department of Infectious Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Joint International Laboratory of Infection and Immunity,Huazhong University of Science and Technology,Wuhan 430022,China
文献出处：
引用格式：
[1]Tiandan Xiang;Junzhong Wang;Xin Zheng-.The humoral and cellular immune evasion of SARS-CoV-2 Omicron and sub-lineages)[J].中国病毒学,2022(06):786-795
A类：
subvariants
B类：
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AB值：
0.607867
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