典型文献
Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment
文献摘要：
Helicobacter pylori(H.pylori),creating a global infection rate over 50％,presents great chal-lenges in clinical therapies due to its complex pathological microenvironment in vivo.To improve the eradication efficacy,herein we fabricated a pharmaceutical vesicle RHL/Cl-Ch-cal where cholesterol-PEG,calcitriol and first-line antibiotic clarithromycin were co-loaded in the rhamnolipid-composed outer lipid layer.RHL/Cl-Ch-cal could quickly penetrate through gastric mucus layer to reach H.pylori infec-tion sites,and then effectively destroyed the architecture of H.pylori biofilms,killed dispersed H.pylori and inhibited the re-adhesion of residual bacteria(called biofilms eradication tetralogy).Moreover,RHL/Cl-Ch-cal activated the host immune response to H.pylori by replenishing cholesterol to repair lipid raft on the cell membrane of host epithelial cells.Finally,RHL/Cl-Ch-cal killed the intracellular H.pylori through recovering the lysosomal acidification and assisting degradation.In experiments,RHL/Cl-Ch-cal demonstrated prominent anti-H.pylori efficacy in the classical H.pylori-infected mice model.There-fore,the study provides a"comprehensive attack"strategy for anti-H.pylori therapies including biofilms eradication tetralogy,immune activation and intracellular bacteria killing.
文献关键词：
中图分类号：
作者姓名：
Xiaonan Chen;Yiqing Zou;Shuqi Zhang;Pengchao Fang;Shuxuan Li;Pengyu Li;Yingying Sun;Gang Yuan;Haiyan Hu
作者机构：
Lab of Pharmaceutics,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China;Phase I Clinical Trial Center,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China;Department of Geriatrics,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China;Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery,Sun Yat-sen University,Guangzhou 510006,China
文献出处：
引用格式：
[1]Xiaonan Chen;Yiqing Zou;Shuqi Zhang;Pengchao Fang;Shuxuan Li;Pengyu Li;Yingying Sun;Gang Yuan;Haiyan Hu-.Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment)[J].药学学报（英文版）,2022(09):3498-3512
A类：
calcitriol,clarithromycin,rhamnolipid
B类：
Multi,functional,vesicles,improve,Helicobacter,pylori,eradication,by,comprehensive,strategy,complex,pathological,microenvironment,creating,global,infection,presents,great,chal,lenges,clinical,therapies,due,its,vivo,To,efficacy,herein,fabricated,pharmaceutical,RHL,Cl,Ch,where,cholesterol,PEG,first,line,antibiotic,were,loaded,composed,outer,layer,could,quickly,penetrate,through,gastric,mucus,reach,sites,then,effectively,destroyed,architecture,biofilms,killed,dispersed,inhibited,adhesion,residual,bacteria,called,tetralogy,Moreover,activated,host,immune,response,replenishing,repair,raft,membrane,epithelial,cells,Finally,intracellular,recovering,lysosomal,acidification,assisting,degradation,In,experiments,demonstrated,prominent,classical,infected,mice,model,There,fore,study,provides,attack,including,activation,killing
AB值：
0.534535
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
