典型文献
Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model
文献摘要：
Platelets buoy up cancer metastasis via arresting cancer cells,enhancing their adhesion,and facilitating their extravasation through the vasculature.When deprived of intracellular and granular con-tents,platelet decoys could prevent metastatic tumor formation.Inspired by these,we developed nano-platesomes by fusing platelet membranes with lipid membranes(P-Lipo)to restrain metastatic tumor formation more efficiently.It was shown nanoplateletsomes bound with circulating tumor cells(CTC)efficiently,interfered with CTC arrest by vessel endothelial cells,CTC extravasation through endothelial layers,and epithelial-mesenchymal transition of tumor cells as nanodecoys.More importantly,in the mouse breast tumor metastasis model,nanoplateletsomes could decrease CTC survival in the blood and counteract metastatic tumor growth efficiently by inhibiting the inflammation and suppressing CTC escape.Therefore,nanoplatelesomes might usher in a new avenue to suppress lung metastasis.
文献关键词：
中图分类号：
作者姓名：
Longlong Zhang;Yuefei Zhu;Xunbin Wei;Xing Chen;Yang Li;Ying Zhu;Jiaxuan Xia;Yiheng Huang;Yongzhuo Huang;Jianxin Wang;Zhiqing Pang
作者机构：
Department of Pharmaceutics,School of Pharmacy,Fudan University,Shanghai 201203,China;Key Laboratory of Smart Drug Delivery,Ministry of Education,Shanghai 201203,China;State Key Laboratory of Oncogenes and Related Genes,Shanghai Cancer Institute,Med-X Research Institute and School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200030,China;State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;Institute of Materia Medica,Academy of Chinese and Western Integrative Medicine,Fudan University,Shanghai 201203,China
文献出处：
引用格式：
[1]Longlong Zhang;Yuefei Zhu;Xunbin Wei;Xing Chen;Yang Li;Ying Zhu;Jiaxuan Xia;Yiheng Huang;Yongzhuo Huang;Jianxin Wang;Zhiqing Pang-.Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model)[J].药学学报（英文版）,2022(08):3427-3447
A类：
Nanoplateletsomes,decoys,platesomes,nanoplateletsomes,nanodecoys,nanoplatelesomes
B类：
restrain,metastatic,tumor,formation,through,active,targeting,preclinical,mouse,model,Platelets,buoy,cancer,metastasis,via,arresting,cells,enhancing,their,adhesion,facilitating,extravasation,vasculature,When,deprived,intracellular,granular,con,tents,could,prevent,Inspired,by,these,we,developed,fusing,membranes,lipid,Lipo,more,efficiently,It,was,shown,bound,circulating,CTC,interfered,vessel,endothelial,layers,epithelial,mesenchymal,transition,More,importantly,breast,decrease,survival,blood,counteract,growth,inhibiting,inflammation,suppressing,escape,Therefore,might,usher,new,avenue,lung
AB值：
0.547221
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