典型文献
Inhibiting collagen I production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles
文献摘要：
The lung is one of the most common sites for cancer metastasis.Collagens in the lung pro-vide a permissive microenvironment that supports the colonization and outgrowth of disseminated tumor cells.Therefore,down-regulating the production of collagens may contribute to the inhibition of lung metastasis.It has been suggested that miR-29 exhibits effective anti-fibrotic activity by negatively regu-lating the expression of collagens.Indeed,our clinical lung tumor data shows that miR-29a-3p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients'outcomes.However,suitable carriers need to be selected to deliver this therapeutic miRNA to the lungs.In this study,we found that the chemotherapy drug cisplatin facilitated miR-29a-3p accumulation in the exosomes of lung tumor cells,and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation.To scale up the preparation and simplify the delivery system,we designed a lung-targeting liposomal nanovesicle(by adjusting the molar ratio of DOTAP/cholesterol-miRNAs to 4:1)to carry miR-29a-3p and mimic the exosomes.This liposomal nanovesicle delivery system significantly down-regulated collagen I secretion by lung fibroblasts in vivo,thus alleviating the establishment of a pro-metastatic environment for circulating lung tumor cells.
文献关键词：
中图分类号：
作者姓名：
Yan Yan;Cancan Du;Xixi Duan;Xiaohan Yao;Jiajia Wan;Ziming Jiang;Zhongyu Qin;Wenqing Li;Longze Pan;Zhuoyu Gu;Fazhan Wang;Ming Wang;Zhihai Qin
作者机构：
Medical Research Center,the First Affiliated Hospital of Zhengzhou University,Zhengzhou University,Zhengzhou 450052,China;Academy of Medical Sciences,Zhengzhou University,Zhengzhou 450052,China;Department of Urology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou University,Zhengzhou 450052,China;Changzhi Medical College,Changzhi 046000,China;Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China
文献出处：
引用格式：
[1]Yan Yan;Cancan Du;Xixi Duan;Xiaohan Yao;Jiajia Wan;Ziming Jiang;Zhongyu Qin;Wenqing Li;Longze Pan;Zhuoyu Gu;Fazhan Wang;Ming Wang;Zhihai Qin-.Inhibiting collagen I production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles)[J].药学学报（英文版）,2022(02):939-951
A类：
Collagens,nanovesicle
B类：
Inhibiting,production,colonization,29a,3p,loading,liposome,nanovesicles,one,most,common,sites,cancer,metastasis,vide,permissive,microenvironment,that,supports,outgrowth,disseminated,cells,Therefore,down,regulating,collagens,may,contribute,inhibition,It,has,been,suggested,exhibits,effective,anti,fibrotic,activity,by,negatively,expression,Indeed,our,clinical,data,shows,correlates,tumors,positively,patients,outcomes,However,suitable,carriers,need,selected,this,therapeutic,lungs,study,found,chemotherapy,drug,cisplatin,facilitated,accumulation,exosomes,type,exhibited,specific,targeting,promising,regulation,To,scale,preparation,simplify,delivery,system,designed,liposomal,adjusting,molar,DOTAP,cholesterol,miRNAs,carry,mimic,This,significantly,regulated,secretion,fibroblasts,vivo,thus,alleviating,establishment,metastatic,circulating
AB值：
0.523022
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
