典型文献
TGR5 deficiency activates antitumor immunity in non-small cell lung cancer via restraining M2 macrophage polarization
文献摘要：
The bile acid-responsive G-protein-coupled receptor TGR5 is expressed in monocytes and macrophages,and plays a critical role in regulating inflammatory response.Our previous work has shown its role in promoting the progression of non-small cell lung cancer(NSCLC),yet the mechanism remains unclear.Here,using Tgr5-knockout mice,we show that TGR5 is required for M2 polarization of tumor-associated macrophages(TAMs)and suppresses antitumor immunity in NSCLC via involving TAMs-mediated CD8+T cell suppression.Mechanistically,we demonstrate that TGR5 promotes TAMs into protumorigenic M2-like phenotypes via activating cAMP-STAT3/STAT6 signaling.Induction of cAMP production restores M2-like phenotypes in TGR5-deficient macrophages.In NSCLC tissues from human patients,the expression of TGR5 is associated with the infiltration of TAMs.The co-expression of TGR5 and high TAMs infiltration are associated with the prognosis and overall survival of NSCLC patients.Together,this study provides molecular mechanisms for the protumor function of TGR5 in NSCLC,high-lighting its potential as a target for TAMs-centric immunotherapy in NSCLC.
文献关键词：
中图分类号：
作者姓名：
Lifang Zhao;Hongyan Zhang;Xueqing Liu;Shan Xue;Dongfang Chen;Jing Zou;Handong Jiang
作者机构：
Department of Respiratory and Critical Care Medicine,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China
文献出处：
引用格式：
[1]Lifang Zhao;Hongyan Zhang;Xueqing Liu;Shan Xue;Dongfang Chen;Jing Zou;Handong Jiang-.TGR5 deficiency activates antitumor immunity in non-small cell lung cancer via restraining M2 macrophage polarization)[J].药学学报（英文版）,2022(02):787-800
A类：
Tgr5,protumorigenic,protumor
B类：
TGR5,deficiency,activates,antitumor,immunity,small,cell,lung,cancer,via,restraining,M2,polarization,bile,acid,responsive,protein,coupled,receptor,expressed,monocytes,macrophages,plays,critical,role,regulating,inflammatory,response,Our,previous,work,has,shown,its,promoting,progression,NSCLC,yet,remains,unclear,Here,using,knockout,mice,we,that,required,associated,TAMs,suppresses,involving,mediated,CD8+T,suppression,Mechanistically,demonstrate,promotes,into,like,phenotypes,activating,cAMP,STAT3,STAT6,signaling,Induction,production,restores,deficient,tissues,from,human,patients,expression,infiltration,high,are,prognosis,overall,survival,Together,this,study,provides,molecular,mechanisms,function,lighting,potential,target,centric,immunotherapy
AB值：
0.542424
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