典型文献
Apolipoprotein E and Alzheimer's disease
文献摘要：
Genetic variation in apolipoprotein E(APOE)influences Alzheimer's disease(AD)risk.APOE e4 alleles are the strongest genetic risk factor for late onset sporadic AD.The AD risk is dose dependent,as those carrying one APOE ε4 allele have a 2-3-fold increased risk,while those carrying two ε4 alleles have a 10-15-fold increased risk.Individuals carrying APOE ε2 alleles have lower AD risk and those carrying APOE ε3 alleles have neutral risk.APOE is a lipoprotein which functions in lipid transport,metabolism,and inflammatory modulation.Isoform specific effects of APOE within the brain include alterations to Aβ,tau,neuroinflammation,and metabolism.Here we review the association of APOE with AD,the APOE isoform specific effects within brain and periphery,and potential therapeutics.
文献关键词：
中图分类号：
作者姓名：
Benjamin R.Troutwine;Laylan Hamid;Colton R.Lysaker;Taylor A.Strope;Heather M.Wilkins
作者机构：
Department of Neurology University of Kansas Medical Center Kansas City,KS 66160,USA;University of Kansas Alzheimer's Disease Center Kansas City,KS 66160,USA;Department of Biochemistry and Molecular Biology,University of Kansas Medical Center Kansas City,KS 66160,USA
文献出处：
引用格式：
[1]Benjamin R.Troutwine;Laylan Hamid;Colton R.Lysaker;Taylor A.Strope;Heather M.Wilkins-.Apolipoprotein E and Alzheimer's disease)[J].药学学报（英文版）,2022(02):496-510
A类：
e4,Isoform
B类：
Apolipoprotein,Alzheimer,disease,Genetic,variation,apolipoprotein,APOE,influences,AD,risk,alleles,are,strongest,genetic,late,onset,sporadic,dose,dependent,those,carrying,one,have,fold,increased,while,two,Individuals,lower,neutral,which,functions,lipid,transport,metabolism,inflammatory,modulation,specific,effects,within,brain,include,alterations,tau,neuroinflammation,Here,review,association,isoform,periphery,potential,therapeutics
AB值：
0.486106
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