典型文献
The osteogenic niche-targeted arsenic nanoparticles prevent colonization of disseminated breast tumor cells in the bone
文献摘要：
Up to 70％of patients with late-stage breast cancer have bone metastasis.Current treatment regimens for breast cancer bone metastasis are palliative with no therapeutic cure.Disseminated tumor cells(DTCs)colonize inside the osteogenic niches in the early stage of bone metastasis.Drug delivery into osteogenic niches to inhibit DTC colonization can prevent bone metastasis from entering its late stage and therefore cure bone metastasis.Here,we constructed a 50％DSS6 peptide conjugated nanopar-ticle to target the osteogenic niche.The osteogenic niche was always located at the endosteum with immature hydroxyapatite.Arsenic-manganese nanocrystals(around 14 nm)were loaded in osteogenic niche-targeted PEG-PLGA nanoparticles with an acidic environment-triggered arsenic release.Arsenic formulations greatly reduced 4T1 cell adhesion to mesenchymal stem cells(MSCs)/preosteoblasts(pre-OBs)and osteogenic differentiation of osteoblastic cells.Arsenic formulations also prevented tumor cell colonization and dormancy via altering the direct interaction between 4T1 cells and MSCs/pre-OBs.The chemotactic migration of 4T1 cells toward osteogenic cells was blocked by arsenic in mimic 3D osteogenic niche.Systemic administration of osteogenic niche-targeted arsenic nanoparticles significantly extended the survival of mice with 4T1 syngeneic bone metastasis.Our findings provide an effective approach for osteogenic niche-specific drug delivery and suggest that bone metastasis can be effectively inhibited by blockage of tumor cell colonization in the bone microenvironment.
文献关键词：
中图分类号：
作者姓名：
Cong Liu;Anzhi Hu;Huijuan Chen;Jing Liang;Mancang Gu;Yang Xiong;Chao-Feng Mu
作者机构：
School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China;Center for Synthetic Biochemistry,Shenzhen Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province,Wenzhou Institute of Biomaterials and Engineering,Wenzhou 325011,China
文献出处：
引用格式：
[1]Cong Liu;Anzhi Hu;Huijuan Chen;Jing Liang;Mancang Gu;Yang Xiong;Chao-Feng Mu-.The osteogenic niche-targeted arsenic nanoparticles prevent colonization of disseminated breast tumor cells in the bone)[J].药学学报（英文版）,2022(01):364-377
A类：
DTCs,DSS6,endosteum,preosteoblasts,syngeneic
B类：
osteogenic,targeted,arsenic,nanoparticles,colonization,disseminated,breast,tumor,cells,bone,Up,patients,late,stage,cancer,have,metastasis,Current,treatment,regimens,are,palliative,therapeutic,cure,Disseminated,colonize,inside,niches,early,Drug,delivery,into,from,entering,its,therefore,Here,constructed,peptide,conjugated,was,always,located,immature,hydroxyapatite,Arsenic,manganese,nanocrystals,around,were,loaded,PEG,PLGA,acidic,triggered,release,formulations,greatly,reduced,4T1,adhesion,mesenchymal,MSCs,OBs,differentiation,osteoblastic,also,prevented,dormancy,via,altering,direct,interaction,between,chemotactic,migration,toward,blocked,by,mimic,Systemic,administration,significantly,extended,survival,mice,Our,findings,provide,approach,specific,drug,suggest,that,effectively,inhibited,blockage,microenvironment
AB值：
0.452416
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