典型文献
A NIR fluorescent probe for Vanin-1 and its applications in imaging,kidney injury diagnosis,and the development of inhibitor
文献摘要：
Vanin-1 is an amidohydrolase that catalyses the conversion of pantetheine into the amino-thiol cysteamine and pantothenic acid(coenzyme A precursor),which plays a vital role in multiple phys-iological and pathological processes.In this study,an enzyme-activated near-infrared(NIR)fluorescent probe(DDAV)has been constructed for sensitively detecting Vanin-1 activity in complicated biosamples on the basis of its catalytic characteristics.DDAV exhibited a high selectivity and sensitivity toward Vanin-1 and was successfully applied to the early diagnosis of kidney injury in cisplatin-induced kidney injury model.In addition,DDAV could serve as a visual tool for in situ imaging endogenous Vanin-1 in vivo.More importantly,Enterococcus faecalis 20247 which possessed high expression of Vanin-1 was screened out from intestinal bacteria using DDAV,provided useful guidance for the rational use of NSAIDs in clinic.Finally,oleuropein as a potent natural inhibitor for Vanin-1 was discovered from herbal medicines library using a high-throughput screening method using DDAV,which held great prom-ise for clinical therapy of inflammatory bowel disease.
文献关键词：
中图分类号：
作者姓名：
Zhenhao Tian;Fei Yan;Xiangge Tian;Lei Feng;Jingnan Cui;Sa Deng;Baojing Zhang;Tian Xie;Shanshan Huang;Xiaochi Ma
作者机构：
Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention,The Second Affiliated Hospital,College of Integrative Medicine,College of Pharmacy,Dalian Medical University,Dalian 116044,China;Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy,Xuzhou Medical University,Xuzhou 221004,China;School of Life Sciences,Northwestern Polytechnical University,Xi'an 710072,China;School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007,China;State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116024,China;College of Pharmacy,Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines,Hangzhou Normal University,Hangzhou 311121,China
文献出处：
引用格式：
[1]Zhenhao Tian;Fei Yan;Xiangge Tian;Lei Feng;Jingnan Cui;Sa Deng;Baojing Zhang;Tian Xie;Shanshan Huang;Xiaochi Ma-.A NIR fluorescent probe for Vanin-1 and its applications in imaging,kidney injury diagnosis,and the development of inhibitor)[J].药学学报（英文版）,2022(01):316-325
A类：
Vanin,amidohydrolase,catalyses,pantetheine,DDAV,biosamples,oleuropein,ise
B类：
NIR,fluorescent,probe,its,applications,imaging,kidney,injury,diagnosis,development,inhibitor,that,conversion,into,amino,thiol,cysteamine,pantothenic,acid,coenzyme,precursor,which,plays,vital,role,multiple,phys,iological,pathological,processes,In,this,study,activated,near,infrared,has,been,constructed,sensitively,detecting,activity,complicated,basis,catalytic,characteristics,exhibited,high,selectivity,sensitivity,toward,was,successfully,applied,early,cisplatin,induced,model,addition,could,serve,visual,tool,situ,endogenous,vivo,More,importantly,Enterococcus,faecalis,possessed,expression,screened,out,from,intestinal,bacteria,using,provided,useful,guidance,rational,NSAIDs,Finally,potent,natural,discovered,herbal,medicines,library,throughput,screening,method,held,great,prom,clinical,therapy,inflammatory,bowel,disease
AB值：
0.570974
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