典型文献
A type Ⅲ-E CRISPR Craspase exhibiting RNase and protease activities
文献摘要：
Type Ⅲ-E CRISPR-Cas effector gRAMP/Cas7-11 is a RNA-guided RNA endonuclease associated with a putative caspase-like protease TRP-CHAT/Csx29,which targets endogenous protein substrate Csx30.In a recent paper published in Science,the Ailong Ke lab has captured cryo-EM snapshots of the nuclease-protease complex Craspase in both resting and different functional states;this paper together with four other related studies have elucidated the molecular mechanisms of both target RNA cleavage and RNA-mediated allosteric regulation of protease catalytic activity,thereby highlighting RNA-dependent protease-based programmed cell death.
文献关键词：
中图分类号：
作者姓名：
Hui Yang;Dinshaw J.Patel
作者机构：
State Key Laboratory of Molecular Biology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai,China;Structural Biology Program,Memorial Sloan-Kettering Cancer Center,New York,NY,USA
文献出处：
引用格式：
[1]Hui Yang;Dinshaw J.Patel-.A type Ⅲ-E CRISPR Craspase exhibiting RNase and protease activities)[J].细胞研究（英文版）,2022(12):1044-1046
A类：
Craspase,gRAMP,Cas7,Csx29,Csx30,Ailong
B类：
type,CRISPR,exhibiting,RNase,protease,activities,Type,effector,guided,endonuclease,associated,putative,caspase,like,TRP,CHAT,which,targets,endogenous,protein,substrate,In,recent,paper,published,Ke,lab,has,captured,cryo,EM,snapshots,complex,both,resting,different,functional,states,this,together,four,other,related,studies,have,elucidated,molecular,mechanisms,cleavage,mediated,allosteric,regulation,catalytic,activity,thereby,highlighting,dependent,programmed,cell,death
AB值：
0.630559
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
