One of the most interesting yet only partially understood issues in biology is how the information in DNA is efficiently and accurately replicated with few enough mistakes to prevent disaster while allowing evolution.Interesting new insights into this issue have recently emerged from an elegant study by Yeeles and colleagues revealing how a subset of human proteins efficiently replicate DNA. Did you ever wonder how dinosaurs or other organisms who lived millions of years ago replicated their DNA,or what can go wrong during nuclear DNA replication to initiate tumor formation in humans?Because life on earth as we now know depends on maintaining the information content in DNA,these are but two of many interesting questions whose answers will require a better understanding of how DNA replication occurs in a rapid,efficient,and accurate manner.This subject has and will continue to entertain some of the brightest scientific minds in the world,using the very best available scientific tools,encompassing structural biology,biochemistry,genetics,and genomics.Ever since Watson and Crick first described the structure of DNA in 1953,1such studies have provided a general idea how DNA replication works in all three kingdoms of life.As but one example,we now know that many proteins are involved in replicating both strands of the duplex DNA comprising the human nuclear genome.Exactly how this enormous and very complex task occurs remains a key goal for the future.

Thomas A.Kunkel

Genome Integrity and Structural Biology Laboratory,National Institute of Environmental Health Sciences,National Institutes of Health,Department of Health and Human Services,Research Triangle Park,NC,USA

细胞研究（英文版）

[1]Thomas A.Kunkel-.Efficient replication of human nuclear DNA)[J].细胞研究（英文版）,2022(09):797-798

Yeeles, Did,entertain,1such,Exactly

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