典型文献
Synthetic lethal screening identifies DHODH as a target for MEN1-mutated tumor cells
文献摘要：
Dear Editor,
Multiple endocrine neoplasia 1(MEN1)syndrome,a tumor predisposition disease caused by MEN1 germline mutation,is characterized by combined occurrence of neuroendocrine tumors(NETs)in multiple organs.1 Pancreatic neuroendocrine tumors(PanNETs)are the major cause of the increased mortality in MEN1 patients due to the most malignant potential.1,2 Treatment of NETs with MEN1 is challenging due to concomitant development of multiple tumors and the limited treatment efficiency,where first-line therapy of somatostatin analogues(SSA)shows no more than 10％objective response rate.2 Improved treatments for MEN1 NETs are urgently required.
文献关键词：
中图分类号：
作者姓名：
Yarui Ma;Qing Zhu;Xiaobing Wang;Mei Liu;Qichen Chen;Liming Jiang;Yihebali Chi;Yi-Xin Zeng;Hong Zhao;Yuchen Jiao
作者机构：
State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;Department of Medical Oncology,Beijing Hospital,National Center of Gerontology and Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing,China;Department of Clinical Laboratory Diagnostics,Beijing Friendship Hospital,Capital Medical University,Beijing,China;Key Laboratory of Gene Editing Screening and R&D of Digestive System Tumor Drugs,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;Department of Hepatobiliary Surgery,State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;Department of Diagnostic Imaging,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,Sun Yat-sen University Cancer Center,Guangzhou,China;Department of Clinical Laboratory,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China
文献出处：
引用格式：
[1]Yarui Ma;Qing Zhu;Xiaobing Wang;Mei Liu;Qichen Chen;Liming Jiang;Yihebali Chi;Yi-Xin Zeng;Hong Zhao;Yuchen Jiao-.Synthetic lethal screening identifies DHODH as a target for MEN1-mutated tumor cells)[J].细胞研究（英文版）,2022(06):596-599
A类：
Multiple,PanNETs
B类：
Synthetic,lethal,screening,identifies,DHODH,target,MEN1,mutated,cells,Dear,Editor,neoplasia,syndrome,predisposition,disease,caused,by,germline,mutation,characterized,combined,occurrence,neuroendocrine,tumors,multiple,organs,Pancreatic,are,major,increased,mortality,patients,due,most,malignant,potential,Treatment,challenging,concomitant,development,limited,efficiency,where,first,therapy,somatostatin,analogues,SSA,shows,no,more,than,objective,response,rate,Improved,treatments,urgently,required
AB值：
0.619841
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