典型文献
Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction
文献摘要：
Dear Editor,
The global fight against the COVID-19 pandemic is still in great uncertainty due to the emergence of SARS-CoV-2 variants,especially the variants of concern(VOCs)with changed patho-genicity,increased transmissibility and the resistance to con-valescent/vaccination sera and monoclonal neutralizing antibodies.1,2 As a newly reported VOC,the Omicron variant has caused great concern with 32 mutations in the spike glycoprotein including unprecedented 15 mutations in the receptor-binding domain(RBD),which would have significant impact on the viral infectivity and the protection effects of approved vaccines and therapeutic antibodies.3,4 A detailed description of the Omicron spike and its interactions with ACE2 receptor and neutralizing antibodies is essential for fully understanding the infection and immune escape of the Omicron variant at the molecular level.
文献关键词：
中图分类号：
作者姓名：
Jun Lan;Xinheng He;Yifei Ren;Ziyi Wang;Huan Zhou;Shilong Fan;Chenyou Zhu;Dongsheng Liu;Bin Shao;Tie-Yan Liu;Qisheng Wang;Linqi Zhang;Jiwan Ge;Tong Wang;Xinquan Wang
作者机构：
The Ministry of Education Key Laboratory of Protein Science,Beijing Advanced Innovation Center for Structural Biology,Beijing Frontier Research Center for Biological Structure,Collaborative Innovation Center for Biotherapy,School of Life Sciences,Tsinghua University,Beijing,China;Microsoft Research Asia,Beijing,China;Shanghai Synchrotron Radiation Facility,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai,China;Department of Chemistry,Tsinghua University,Beijing,China;Center for Global Health and Infectious Diseases,Comprehensive AIDS Research Center,and Beijing Advanced Innovation Center for Structural Biology,School of Medicine,Tsinghua University,Beijing,China
文献出处：
引用格式：
[1]Jun Lan;Xinheng He;Yifei Ren;Ziyi Wang;Huan Zhou;Shilong Fan;Chenyou Zhu;Dongsheng Liu;Bin Shao;Tie-Yan Liu;Qisheng Wang;Linqi Zhang;Jiwan Ge;Tong Wang;Xinquan Wang-.Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction)[J].细胞研究（英文版）,2022(06):593-595
A类：
genicity,valescent
B类：
Structural,insights,into,SARS,CoV,Omicron,RBD,ACE2,Dear,Editor,
The,global,fight,against,pandemic,still,great,uncertainty,due,emergence,variants,especially,concern,VOCs,changed,patho,increased,transmissibility,resistance,vaccination,sera,monoclonal,neutralizing,antibodies,newly,reported,has,caused,mutations,spike,glycoprotein,including,unprecedented,receptor,binding,domain,which,would,have,significant,impact,viral,infectivity,protection,effects,approved,vaccines,therapeutic,detailed,description,its,interactions,essential,fully,understanding,infection,immune,escape,molecular,level
AB值：
0.614633
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
