典型文献
Gi-protein-coupled β1-adrenergic receptor:re-understanding the selectivity of β1-adrenergic receptor to G protein
文献摘要：
β1-adrenergic receptor(β1-AR),a member in the family of G-protein-coupled receptors,is a transmembrane receptor of great significance in the heart.Physiologically,catecholamines activate β1-AR to initiate a positive chronotropic,inotropic,and dromotropic change.It is believed that β1-AR couples to Gs protein and transmits the signal through second messenger cAMP.However,increasing research shows that β1-AR can also bind with Gi protein in addition to Gs.When β1-AR-Gi is biasedly activated,cardioprotective effects are introduced by the activated cGMP-protein kinase G(PKG)pathway and the transactivation of epidermal growth factor receptor(EGFR)pathway.The discovery of β1-AR-Gi signaling makes us reconsider the selectivity of G protein with regard to β1-AR,which also provides new ideas for the treatment of heart diseases.This review summarizes the discovery of β1-AR-Gi pathway,including the evidence that supports β1-AR's capability to couple Gi,details of the transduction process and functions of the β1-AR-Gi signaling pathway.
文献关键词：
中图分类号：
作者姓名：
Hao Chen;Suli Zhang;Ruiqi Hou;Huirong Liu
作者机构：
Department of Physiology&Pathophysiology,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China;Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Disease,Capital Medical University,Beijing 100069,China
文献出处：
引用格式：
[1]Hao Chen;Suli Zhang;Ruiqi Hou;Huirong Liu-.Gi-protein-coupled β1-adrenergic receptor:re-understanding the selectivity of β1-adrenergic receptor to G protein)[J].生物化学与生物物理学报（英文版）,2022(08):1043-1048
A类：
Physiologically,chronotropic,dromotropic,biasedly
B类：
Gi,protein,coupled,adrenergic,understanding,selectivity,member,family,receptors,transmembrane,great,significance,heart,catecholamines,initiate,positive,inotropic,change,It,believed,that,couples,Gs,transmits,through,second,messenger,cAMP,However,increasing,research,shows,also,bind,addition,When,activated,cardioprotective,effects,are,introduced,by,cGMP,kinase,PKG,pathway,transactivation,epidermal,growth,EGFR,discovery,signaling,makes,us,reconsider,regard,which,provides,new,ideas,treatment,diseases,This,review,summarizes,including,evidence,supports,capability,details,transduction,process,functions
AB值：
0.519127
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