典型文献
Antigen self-presenting nanovaccine for cancer immunotherapy
文献摘要：
Cancer immunotherapy has made breakthroughs in clinical application and has become the fourth most prevalent tumor treat-ment method after surgical resection,chemotherapy,and radio-therapy.It mainly enhances the anti-tumor immunity of the tumor microenvironment by stimulating or mobilizing the immune system to control and kill tumor cells[1].T lymphocytes are an important component of the body's immune system,which indirectly or directly affects the occurrence and development of tumors,and emerging advances in T lymphocyte-based tumor immunotherapy also attract much more attention.It is a common knowledge that the activation,proliferation,and differentiation of antigen-specific lymphocytes are the key to the successful estab-lishment of anti-tumor immunity,and this process largely depends on the interaction between T cells and antigen-presenting cells(APCs)[1].Activation of CD8+cytotoxic T lymphocytes(CTLs)has proved to be an important role in cancer immunotherapy.Tumor antigens are presented to T cells through major histocompatibility complex class I(MHC-I)molecules on the surface of APCs,thereby stimulating the activation and proliferation of CD8+T cells,and finally producing a strong,sustained,and effective CTL response[2].Therefore,fully mobilizing the function of T lymphocytes is essential for tumor immunotherapy.
文献关键词：
中图分类号：
作者姓名：
Xiaoliu Liang;Hongwei Cheng;Chao Liu;Gang Liu
作者机构：
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361102,China
文献出处：
引用格式：
[1]Xiaoliu Liang;Hongwei Cheng;Chao Liu;Gang Liu-.Antigen self-presenting nanovaccine for cancer immunotherapy)[J].科学通报（英文版）,2022(16):1611-1613
A类：
nanovaccine,lishment,CD8+cytotoxic
B类：
Antigen,self,presenting,cancer,immunotherapy,Cancer,has,made,breakthroughs,clinical,application,become,fourth,most,prevalent,treat,method,after,surgical,resection,chemotherapy,radio,It,mainly,enhances,immunity,microenvironment,stimulating,mobilizing,immune,system,control,kill,cells,lymphocytes,are,important,component,body,which,indirectly,affects,occurrence,development,tumors,emerging,advances,also,attract,much,more,attention,common,knowledge,that,activation,proliferation,differentiation,specific,key,successful,estab,this,process,largely,depends,interaction,between,APCs,Activation,CTLs,proved,role,Tumor,antigens,presented,major,histocompatibility,complex,class,MHC,molecules,surface,thereby,CD8+T,finally,producing,strong,sustained,effective,response,Therefore,fully,function,essential
AB值：
0.561633
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
