典型文献
Genomic Shift in Population Dynamics of mcr-1-positive Escherichia coli in Human Carriage
文献摘要：
Emergence of the colistin resistance gene,mcr-1,has attracted worldwide attention.Despite the prevalence of mcr-1-positive Escherichia coli(MCRPEC)strains in human carriage showing a significant decrease between 2016 and 2019,genetic differences in MCRPEC strains remain largely unknown.We therefore conducted a comparative genomic study on MCRPEC strains from fecal samples of healthy human subjects in 2016 and 2019.We identified three major differences in MCRPEC strains between these two time points.First,the insertion sequenceISApll1 was often deleted and the percentage of mcr-1-carrying IncI2 plasmids was increased in MCRPEC strains in 2019.Second,the antibiotic resistance genes(ARGs),aac(3)-Ⅳa and blaCTX-M-1,emerged and coexisted with mcr-1 in 2019.Third,MCRPEC strains in 2019 contained more viru-lence genes,resulting in an increased proportion of extraintestinal pathogenic E.coli(ExPEC)strains(36.1％)in MCRPEC strains in 2019 compared to that in 2016(10.5％),implying that these strains could occupy intestinal ecological niches by competing with other commensal bacteria.Our results suggest that despite the significant reduction in the prevalence of MCRPEC strains in humans from 2016 to 2019,MCRPEC exhibits increased resistance to other clinically important ARGs and contains more virulence genes,which may pose a potential public health threat.
文献关键词：
中图分类号：
作者姓名：
Yingbo Shen;Rong Zhang;Dongyan Shao;Lu Yang;Jiayue Lu;Congcong Liu;Xueyang Wang;Junyao Jiang;Boxuan Wang;Congming Wu;Julian Parkhill;Yang Wang;Timothy R.Walsh;George F.Gao;Zhangqi Shen
作者机构：
College of Veterinary Medicine,China Agricultural University,Beijing 100193,China;Guangdong Laboratory for Lingnan Modern Agriculture,Guangzhou 510641,China;CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China;The Second Affiliated Hospital of Zhejiang University School of Medicine,Zhejiang University,Hangzhou 310009,China;Department of Veterinary Medicine,University of Cambridge,Cambridge CB3 0ES,UK;Department of Biology,University of Oxford,Oxford OX1 3SZ,UK;Chinese Center for Disease Control and Prevention,Beijing 102206,China
文献出处：
引用格式：
[1]Yingbo Shen;Rong Zhang;Dongyan Shao;Lu Yang;Jiayue Lu;Congcong Liu;Xueyang Wang;Junyao Jiang;Boxuan Wang;Congming Wu;Julian Parkhill;Yang Wang;Timothy R.Walsh;George F.Gao;Zhangqi Shen-.Genomic Shift in Population Dynamics of mcr-1-positive Escherichia coli in Human Carriage)[J].基因组蛋白质组与生物信息学报（英文版）,2022(06):1168-1179
A类：
Carriage,MCRPEC,sequenceISApll1
B类：
Genomic,Shift,Population,Dynamics,mcr,positive,Escherichia,Human,Emergence,colistin,resistance,has,attracted,worldwide,attention,Despite,prevalence,strains,carriage,showing,significant,decrease,between,genetic,differences,remain,largely,unknown,We,therefore,conducted,comparative,genomic,study,from,fecal,samples,healthy,subjects,identified,three,major,these,two,points,First,insertion,was,often,deleted,percentage,carrying,IncI2,plasmids,increased,Second,antibiotic,genes,ARGs,aac,blaCTX,emerged,coexisted,Third,contained,more,resulting,proportion,extraintestinal,pathogenic,ExPEC,compared,that,implying,could,occupy,ecological,niches,by,competing,other,commensal,bacteria,Our,results,suggest,despite,reduction,humans,exhibits,clinically,important,contains,virulence,which,may,pose,potential,public,threat
AB值：
0.552832
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
