典型文献
Over 50,000 Metagenomically Assembled Draft Genomes for the Human Oral Microbiome Reveal New Taxa
文献摘要：
The oral cavity of each person is home to hundreds of bacterial species.While taxa for oral diseases have been studied using culture-based characterization as well as amplicon sequencing,metagenomic and genomic information remains scarce compared to the fecal microbiome.Here,using metagenomic shotgun data for 3346 oral metagenomic samples together with 808 published samples,we obtain 56,213 metagenome-assembled genomes(MAGs),and more than 64％of the 3589 species-level genome bins(SGBs)contain no publicly available genomes.The resulting genome collection is representative of samples around the world and contains many genomes from candi-date phyla radiation(CPR)that lack monoculture.Also,it enables the discovery of new taxa such as a genus Candidatus Bgiplasma within the family Acholeplasmataceae.Large-scale metagenomic data from massive samples also allow the assembly of strains from important oral taxa such as Por-phyromonas and Neisseria.The oral microbes encode genes that could potentially metabolize drugs.Apart from these findings,a strongly male-enriched Campylobacter species was identified.Oral sam-ples would be more user-friendly collected than fecal samples and have the potential for disease diagnosis.Thus,these data lay down a genomic framework for future inquiries of the human oral microbiome.
文献关键词：
中图分类号：
作者姓名：
Jie Zhu;Liu Tian;Peishan Chen;Mo Han;Liju Song;Xin Tong;Xiaohuan Sun;Fangming Yang;Zhipeng Lin;Xing Liu;Chuan Liu;Xiaohan Wang;Yuxiang Lin;Kaiye Cai;Yong Hou;Xun Xu;Huanming Yang;Jian Wang;Karsten Kristiansen;Liang Xiao;Tao Zhang;Huijue Jia;Zhuye Jie
作者机构：
BGI-Shenzhen,Shenzhen 518083,China;Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research,BGI-Shenzhen,Shenzhen 518083,China;Shenzhen Engineering Laboratory of Detection and Intervention of Human Intestinal Microbiome,BGI-Shenzhen,Shenzhen 518083,China;Laboratory of Genomics and Molecular Biomedicine,Department of Biology,University of Copenhagen,Copenhagen DK-2100,Denmark;James D.Watson Institute of Genome Sciences,Hangzhou 310058,China;BGI-Qingdao,BGI-Shenzhen,Qingdao 266555,China
文献出处：
引用格式：
[1]Jie Zhu;Liu Tian;Peishan Chen;Mo Han;Liju Song;Xin Tong;Xiaohuan Sun;Fangming Yang;Zhipeng Lin;Xing Liu;Chuan Liu;Xiaohan Wang;Yuxiang Lin;Kaiye Cai;Yong Hou;Xun Xu;Huanming Yang;Jian Wang;Karsten Kristiansen;Liang Xiao;Tao Zhang;Huijue Jia;Zhuye Jie-.Over 50,000 Metagenomically Assembled Draft Genomes for the Human Oral Microbiome Reveal New Taxa)[J].基因组蛋白质组与生物信息学报（英文版）,2022(02):246-259
A类：
Metagenomically,Draft,SGBs,Bgiplasma,Acholeplasmataceae,phyromonas,inquiries
B类：
Over,Assembled,Genomes,Human,Oral,Microbiome,Reveal,New,Taxa,oral,cavity,each,person,home,hundreds,bacterial,species,While,taxa,diseases,have,been,studied,using,characterization,well,amplicon,sequencing,metagenomic,information,remains,scarce,compared,fecal,microbiome,Here,shotgun,data,samples,together,published,obtain,metagenome,assembled,genomes,MAGs,more,than,level,bins,publicly,available,resulting,collection,representative,around,world,contains,many,from,candi,date,phyla,radiation,CPR,that,lack,monoculture,Also,enables,discovery,new,such,genus,Candidatus,within,family,Large,scale,massive,also,allow,assembly,strains,important,Por,Neisseria,microbes,encode,genes,could,potentially,metabolize,drugs,Apart,these,findings,strongly,male,enriched,Campylobacter,was,identified,would,user,friendly,collected,diagnosis,Thus,lay,down,framework,future,human
AB值：
0.608011
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