典型文献
Lessons learned from hepatocellular carcinoma may cause a paradigm shift in intraductal papillary mucinous neoplasms: a narrative review and discussion of conceptual similarities in tumor progression and recurrence
文献摘要：
Although the natural history of recurrence/progression in patients with intraductal papillary mucinous neoplasms (IPMN) of the pancreas has not been studied thoroughly, the three principal mechanisms have been identified: (a) presence of residual disease at the transection margin, (b) presence of intraductal/intraparenchymal metastases and (c) development of new primary lesions. Mechanisms (a) and (b) result in metastatic lesions that are genetically related to the primary, while new primary lesions (mechanism c) are genetically distinct. Interestingly, recurrence/progression in IPMN displays conceptual parallels with the well-established paradigm of disease recurrence in patients with hepatocellular carcinoma (HCC). Specifically, patients with HCC may also develop recurrent tumors due to microscopic residual disease/intrahepatic metastasis which are genetically similar to the primary while the development of genetically unrelated, de novo HCC after curative-intent resection is also common. The latter has been attributed to the presence of a widespread genetic abnormality ( "field defect" ) in the liver (ie, cirrhosis). Given the conceptual similarities between IPMN and HCC, a pancreatic "field defect" may also be hypothesized to exist. This review does not suggest that HCC and IPMN have identical pathogeneses, but rather that they have conceptual similarities in tumor recurrence/progression; thus, lessons learned from HCC could be applied to IPMN research and subsequent management. Conceptual similarities in tumor progression and recurrence may also be observed between IPMN and other malignancies. However, HCC was selected because it is well studied and can serve as a paradigm.
文献关键词：
Field defect;Hepatocellular carcinoma;Intraductal papillary mucinous neoplasm;Progression;Recurrence
中图分类号：
作者姓名：
Margonis Georgios Antonios;Andreatos Nikolaos;Wang Jane;Weiss Matthew J.;Wolfgang Christopher L.
作者机构：
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY;Department of Internal Medicine and Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;Department of Surgery, University of California San Francisco, San Francisco, CA;Department of Surgery, Northwell Health Cancer Institute and Zucker School of Medicine at Hofstra, Lake Success;Department of Surgery, NYU Grossman School of Medicine, New York, NY, USA
文献出处：
引用格式：
[1]Margonis Georgios Antonios;Andreatos Nikolaos;Wang Jane;Weiss Matthew J.;Wolfgang Christopher L.-.Lessons learned from hepatocellular carcinoma may cause a paradigm shift in intraductal papillary mucinous neoplasms: a narrative review and discussion of conceptual similarities in tumor progression and recurrence)[J].胰腺病学杂志（英文）,2022(01):36-40
A类：
intraparenchymal,pathogeneses
B类：
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AB值：
0.488712
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