典型文献
The exciting and magical journey of components from compound formulae to where they fight
文献摘要：
With its long-term empirical clinical practice and increasing number of health benefits reported,Chinese Materia Medica(CMM)is gaining increasing global acceptance.Importantly,the identification of chemical constituents in vitro and exposed forms in vivo is a prerequisite for understanding how CMM formulae prevent and treat diseases.This review systematically summarizes the exciting and magical journey of CMM components from compound formulae to where they fight,the possible structural transformation of CMM components in vitro and in vivo,and their pharmacological contribution.When a decoction is prepared,significant chemical reactions are observed,including degradation and production of polymers and self-assembling supramolecules,leading to the construction of a component library with diverse decoction structures.After ingestion,compounds pass through the intestinal and blood-brain barriers and undergo a more wonderful journey involving the gut microbiota,microbial enzymes,and endogenous drug-metabolizing enzymes(mainly liver enzymes).At this stage,they are modified and assembled into novel and complex compounds,such as newly generated metabolites,conjugates,and self-assembling superamolecules.This review might provide a strategic orientation to explore the active compounds of CMM formulae in vivo.
文献关键词：
中图分类号：
作者姓名：
Ning Meng;Yun Lyu;Xiaoyu Zhang;Xin Chai;Kefeng Li;Yuefei Wang
作者机构：
State Key Laboratory of Component-based Chinese Medicine,Tianjin Key Laboratory of TCM Chemistry and Analysis,Tianjin University of Traditional Chinese Medicine,Tianjin,China;State Key Laboratory of Core Technology in Innovative Chinese Medicine,Tasly Holding Group Co.,Ltd.,Tianjin,China;School of Medicine,University of California San Diego,La Jolla,CA,USA;Haihe Laboratory of Modern Chinese Medicine,Tianjin,China
文献出处：
引用格式：
[1]Ning Meng;Yun Lyu;Xiaoyu Zhang;Xin Chai;Kefeng Li;Yuefei Wang-.The exciting and magical journey of components from compound formulae to where they fight)[J].针灸和草药（英文）,2022(04):240-252
A类：
supramolecules,superamolecules
B类：
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AB值：
0.62554
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