典型文献
In vitro anti-melanoma effect of polyphenolic compounds
文献摘要：
Objective: To evaluate the effects of phenolic acids (caffeic, ferulic, and coumaric acids) and flavones (luteolin and apigenin) on the proliferation and melanogenesis in murine melanoma B16-F10 cells. Methods: Cell proliferation was determined after 24 and 48 hours of incubation using MTT assay. The effects of these tested compounds on cell cycle progression were analyzed by flow cytometry. Moreover, the melanin content and tyrosinase activity were measured spectrophotometrically at 475 nm. Results: Luteolin and apigenin exhibited significant anti-proliferative activity against B16-F10 cells, while caffeic, ferulic, and coumaric acids induced slight inhibition after 24 and 48 hours of incubation. The tested compounds disturbed cell cycle progression of B16-F10, by a subsequent decrease in G1 and arrested cycle progression in either G1/S or G2/M phase. Furthermore, apigenin provoked an increase in melanin content of B16-F10 cells. In contrast, luteolin, caffeic, ferulic and coumaric acids induced a decrease in melanin content of B16-F10 cells by inhibiting tyrosinase activity. Conclusions: These active polyphenols may be used as skin whitening agents or natural tanning agents to treat skin pigmentation disorders.
文献关键词：
中图分类号：
作者姓名：
Fairouz Sioud;Mouna Maatouk;Imen Mokdad Bzeouich;Leila Chekir Ghedira;Soumaya Kilani-Jaziri
作者机构：
Unit of Bioactive and Natural Substances and Biotechnology UR17ES49,Faculty of Dentistry University of Monastir,Avicenne Street,5019 Monastir,Tunisia;Faculty of Medecine of Monastir University of Monastir,Avicenne Street,5000,Monastir,Tunisia;Department of Pharmaceutical Sciences A, Faculty of Pharmacy of Monastir University of Monastir, Ibn sina Street, 5000, Monastir, Tunisia
文献出处：
引用格式：
[1]Fairouz Sioud;Mouna Maatouk;Imen Mokdad Bzeouich;Leila Chekir Ghedira;Soumaya Kilani-Jaziri-.In vitro anti-melanoma effect of polyphenolic compounds)[J].亚太热带生物医学杂志（英文版）,2022(10):446-452
A类：
spectrophotometrically,tanning
B类：
In,vitro,anti,melanoma,polyphenolic,compounds,Objective,To,evaluate,effects,acids,caffeic,ferulic,coumaric,flavones,luteolin,apigenin,proliferation,melanogenesis,murine,B16,F10,cells,Methods,Cell,was,determined,after,hours,incubation,using,MTT,assay,these,tested,cycle,progression,were,analyzed,by,flow,cytometry,Moreover,melanin,content,tyrosinase,activity,measured,Results,Luteolin,exhibited,significant,proliferative,against,while,induced,slight,inhibition,disturbed,subsequent,decrease,G1,arrested,either,G2,phase,Furthermore,provoked,increase,contrast,inhibiting,Conclusions,These,active,polyphenols,may,used,skin,whitening,agents,natural,treat,pigmentation,disorders
AB值：
0.518682
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