典型文献
Regulation of α-cell glucagon secretion: The role of second messengers
文献摘要：
Glucagon is a potent glucose-elevating hormone that is secreted by pancreatic α- cells. While well-controlled glucagon secretion plays an important role in maintaining systemic glucose homeostasis and preventing hypoglycaemia, it is increasingly apparent that defects in the regulation of glucagon secretion contribute to impaired counter-regulation and hyperglycaemia in diabetes. It has therefore been proposed that pharmacological interventions targeting glucagon secretion/signalling can have great potential in improving glycaemic control of patients with diabetes. However, despite decades of research, a consensus on the precise mechanisms of glucose regulation of glucagon secretion is yet to be reached. Second messengers are a group of small intracellular molecules that relay extracellular signals to the intracellular signalling cascade, modulating cellular functions. There is a growing body of evidence that second messengers, such as cAMP and Ca
2+, play critical roles in α-cell glucose-sensing and glucagon secretion. In this review, we discuss the impact of second messengers on α-cell electrical activity, intracellular Ca
2+ dynamics and cell exocytosis. We highlight the possibility that the interaction between different second messengers may play a key role in the glucose-regulation of glucagon secretion.
文献关键词：
glucagon;pancreatic islet;second messenger
中图分类号：
作者姓名：
Acreman Samuel;Zhang Quan
作者机构：
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UK;Institute of Neuroscience and Physiology, Department of Physiology, Metabolic Research Unit, University of Goteborg, Box 430, S-405 30, G?teborg, Sweden
文献出处：
引用格式：
[1]Acreman Samuel;Zhang Quan-.Regulation of α-cell glucagon secretion: The role of second messengers)[J].慢性疾病与转化医学（英文）,2022(01):7-18
A类：
hypoglycaemia
B类：
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AB值：
0.545085
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
