典型文献
整体分层针刀疗法对KOA患者下肢功能及滑囊液MMP1、MMP13的影响——随机临床试验
文献摘要：
Objective:To observe the differences in clinical effect on knee osteoarthritis(KOA)between the holistic stratification acupotomy and the joint injection with sodium hyaluronate so as to provide a safe and effective treatment for KOA.Methods:A total of 100 KOA patients were randomly divided into an acupotomy group and a sodium hyaluronate group,50 patients in each one.In the acupotomy group,the holistic stratification acupotomy was adopted.In the sodium hyaluronate group,sodium hyaluronate injection was applied in the joints.The index of Western Ontario and McMaster University(WOMAC)and the expressions of MMP1 and MMP13 in bursal fluid of the patients were compared before and after treatment in the patients between two groups before and after treatment,and the clinical therapeutic effect was observed.Results:After treatment,WOMAC score of each dimension and the concentrations of MMP1 and MMP13 in bursal fluid of the patients of either group were all lower than those before treatment(all P＜0.05).After treatment,WOMAC score of each dimension and the concentrations of MMP1 and MMP13 in bursal fluid in the acupotomy group were lower than the sodium hyaluronate group(all P＜0.05).The total effective rate in the acupotomy group was higher than that of the sodium hyaluronate group(P＜0.05).Conclusion:Both the holistic stratification acupotomy and the joint injection with sodium hyaluronate are effective on KOA in this trial.However,the therapeutic effect of holistic stratification acupotomy is remarkable,which is probably related to the improvements in inflammatory response.
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作者姓名：
王一洲;赵强
作者机构：
天津市中医药研究院附属医院,天津300120,中国;天津中医药大学第一附属医院,天津300380,中国
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引用格式：
[1]王一洲;赵强-.整体分层针刀疗法对KOA患者下肢功能及滑囊液MMP1、MMP13的影响——随机临床试验)[J].世界针灸杂志（英文版）,2022(03):218-222
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B类：
针刀疗法,KOA,下肢功能,滑囊,囊液,MMP13,随机临床试验,Objective,To,differences,clinical,knee,osteoarthritis,between,holistic,stratification,acupotomy,injection,sodium,hyaluronate,provide,safe,effective,treatment,Methods,total,patients,were,randomly,divided,into,each,one,In,was,adopted,applied,joints,Ontario,McMaster,University,WOMAC,expressions,bursal,fluid,compared,before,after,two,groups,therapeutic,observed,Results,After,score,dimension,concentrations,either,all,lower,than,those,rate,higher,that,Conclusion,Both,this,trial,However,remarkable,which,probably,related,improvements,inflammatory,response
AB值：
0.34856
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