典型文献
Signaling pathways of adipose stem cell-derived exosomes promoting muscle regeneration
文献摘要：
Severe muscle injury is still a challenging clinical problem. Exosomes derived from adipose stem cells (ASC-exos) may be a potential therapeutic tool, but their mechanism is not completely clear. This review aims to elaborate the possible mechanism of ASC-exos in muscle regeneration from the perspective of signal pathways and provide guidance for further study. Literature cited in this review was acquired through PubMed using keywords or medical subject headings, including adipose stem cells, exosomes, muscle regeneration, myogenic differentiation, myogenesis, wingless/integrated (Wnt), mitogen-activated protein kinases, phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/Akt), Janus kinase/signal transducers and activators of transcription, and their combinations. We obtained the related signal pathways from proteomics analysis of ASC-exos in the literature, and identified that ASC-exos make different contributions to multiple stages of skeletal muscle regeneration by those signal pathways.
文献关键词：
Adipose stem cells;Exosomes;Muscle regeneration;Signaling pathways
中图分类号：
作者姓名：
Zhu Aoxuan;Liu Na;Shang Yujia;Zhen Yonghuan;An Yang
作者机构：
Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China;Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China
文献出处：
引用格式：
[1]Zhu Aoxuan;Liu Na;Shang Yujia;Zhen Yonghuan;An Yang-.Signaling pathways of adipose stem cell-derived exosomes promoting muscle regeneration)[J].中华医学杂志（英文版）,2022(21):2525-2534
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B类：
Signaling,pathways,adipose,stem,derived,exosomes,promoting,muscle,regeneration,Severe,injury,still,challenging,clinical,problem,Exosomes,from,cells,ASC,may,be,potential,therapeutic,tool,their,mechanism,not,completely,clear,This,review,aims,elaborate,possible,perspective,signal,provide,guidance,further,study,Literature,cited,this,was,acquired,through,using,keywords,medical,subject,headings,including,myogenic,differentiation,myogenesis,wingless,integrated,Wnt,mitogen,activated,protein,kinases,phosphatidylinositol,bisphosphate,PI3K,Akt,Janus,transducers,activators,transcription,combinations,We,obtained,related,proteomics,analysis,literature,identified,that,make,contributions,multiple,stages,skeletal,by,those,Adipose,Muscle
AB值：
0.614579
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