典型文献
Functional mutations of SARS-CoV-2: implications to viral transmission, pathogenicity and immune escape
文献摘要：
The pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to major public health challenges globally. The increasing viral lineages identified indicate that the SARS-CoV-2 genome is evolving at a rapid rate. Viral genomic mutations may cause antigenic drift or shift, which are important ways by which SARS-CoV-2 escapes the human immune system and changes its transmissibility and virulence. Herein, we summarize the functional mutations in SARS-CoV-2 genomes to characterize its adaptive evolution to inform the development of vaccination, treatment as well as control and intervention measures.
文献关键词：
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2);Mutation;Variants of concern;Variants of interest;Adaptive evolution
中图分类号：
作者姓名：
Dang Shengyuan;Ren Lili;Wang Jianwei
作者机构：
National Health Commission of the People’s Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China;Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
文献出处：
引用格式：
[1]Dang Shengyuan;Ren Lili;Wang Jianwei-.Functional mutations of SARS-CoV-2: implications to viral transmission, pathogenicity and immune escape)[J].中华医学杂志（英文版）,2022(10):1213-1222
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B类：
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AB值：
0.654838
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