典型文献
Antibody-drug conjugates in HER2-positive breast cancer
文献摘要：
Antibody-drug conjugates (ADCs) combine the high specificity of monoclonal antibodies with the high anti-tumor activity of small molecular cytotoxic payloads. The anti-tumor activity of ADCs is mainly achieved by the direct blocking of the receptor by monoclonal antibodies, direct action and bystander effect of cytotoxic drugs, and antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity. ADCs have been used in adjuvant therapy and rescue treatment of human epidermal receptor 2 (HER2)-positive breast cancer, greatly improving the prognosis of breast cancer patients. Several ongoing clinical trials of ADC for breast cancer and other solid tumors proved the potential of ADCs will provide more promising treatment options for patients with malignant tumors. This review introduces the mechanism and latest clinical progress of ADC drugs approved for HER2-positive breast cancer to guide clinical practice and conduct research.
文献关键词：
Antibody-drug conjugate;HER2-positive;Breast cancer;T-DM1;DS-8201
中图分类号：
作者姓名：
Li Lixi;Zhang Di;Liu Binliang;Lv Dan;Zhai Jingtong;Guan Xiuwen;Yi Zongbi;Ma Fei
作者机构：
Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
文献出处：
引用格式：
[1]Li Lixi;Zhang Di;Liu Binliang;Lv Dan;Zhai Jingtong;Guan Xiuwen;Yi Zongbi;Ma Fei-.Antibody-drug conjugates in HER2-positive breast cancer)[J].中华医学杂志（英文版）,2022(03):261-267
A类：
B类：
Antibody,conjugates,HER2,positive,breast,cancer,ADCs,combine,high,specificity,monoclonal,antibodies,activity,small,molecular,payloads,mainly,achieved,direct,blocking,receptor,action,bystander,effect,drugs,antibody,dependent,cell,mediated,cytotoxicity,complement,have,been,used,adjuvant,therapy,rescue,treatment,human,epidermal,greatly,improving,prognosis,patients,Several,ongoing,clinical,trials,other,solid,tumors,potential,will,provide,more,promising,options,malignant,This,review,introduces,mechanism,latest,progress,approved,guide,practice,conduct,research,Breast,DM1,DS
AB值：
0.534383
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