典型文献
Immunological effects of nano-enabled hyperthermia for solid tumors:opportunity and challenge
文献摘要：
Compared to conventional hyperthermia that is limited by low selectivity and severe side effects,nano-enabled hyperthermia yields great potentials to tackle these limitations for cancer treatment.Another major advance is the observation of immunological responses associated with nano-enabled hyperthermia,which introduces a new avenue,allowing a potential paradigm shift from the acutely effective and cytotoxicity-centric response to the next-phase discovery,i.e.,long-lasting and/or systemic anti-tumor immunity.This perspective first discusses the temperature-gradient and the spatially-structured immuno-logical landscape in solid tumors receiving nano-enabled hyperthermia.This includes the discussion about under-lying mechanism such as immunogenic cell death,which initiates a profound immunological chain reaction.In order to propagate the immune activation as a viable therapeutic principle,we further discussed the tumor type-specific complexity in the immunological tumor microenviron-ment,including the creative design of nano-enabled combination therapy to synergize with nano-enabled hyperthermia.
文献关键词：
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作者姓名：
Xiangsheng Liu;Hui Sun;Xueqing Wang;Huan Meng
作者机构：
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology (NCNST),Beijing 100190,China;The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital),Institute of Basic Medicine and Cancer (IBMC),Chinese Academy of Sciences,Hangzhou 310022,China;Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China
文献出处：
引用格式：
[1]Xiangsheng Liu;Hui Sun;Xueqing Wang;Huan Meng-.Immunological effects of nano-enabled hyperthermia for solid tumors:opportunity and challenge)[J].化学科学与工程前沿,2022(03):333-344
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