Metals have been used for wound treatment and toxicity testing since ancient times.With the develop-ment of nanotechnology,metal oxides have been proven to have excellent sterilization and disinfection functions.However,the rapid bacterial inactivation efficiency and trapping physicochemical killing ability remain simultaneously undemonstrated in antibacterial nanohybrids.Here,we demonstrate a method for in-situ reduction of small-sized Cu2O particles on one-dimensional inorganic halloysite nanotubes(HNTs).The resultant Cu2O@HNTs hybrids not only give Cu2O excellent dispersibility,but also exert the synergis-tic effect of the charge adsorption of metal oxides and the physical piercing effect of the small-sized nanotubes.Furthermore,the release of Cu2+from hybrids damages cell membranes and denatures pro-teins and DNA.Through this sterilization mechanism,Cu2O@HNTs allow for the inactivation rate of Es-cherichia coli to reach 94.5％within 2 min and complete inactivation within 10 min.This excellent steril-ization mode makes Cu2O@HNTs exhibit excellent broad-spectrum antibacterial activity and inactivation efficiency,while shows weak cytotoxicity.These hybrids were further applied in the processing of func-tional antibacterial fibers and fabrics.Thus,we believe that this excellent antibacterial hybrid is practi-cally attractive in this critical time of the COVID-19 pandemic.

Yaping Wang;Qianqian Wang;Guoyi Wu;Hengxue Xiang;Mugaanire Tendo Innocent;Mian Zhai;Chao Jia;Peng Zou;Jialiang Zhou;Meifang Zhu

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Materials Science and Engineering,Donghua University,Shanghai 201620,China;Shanghai Public Health Clinical Center,Fudan University,Shanghai 200540,China

材料科学技术（英文版）

[1]Yaping Wang;Qianqian Wang;Guoyi Wu;Hengxue Xiang;Mugaanire Tendo Innocent;Mian Zhai;Chao Jia;Peng Zou;Jialiang Zhou;Meifang Zhu-.Ultra-fast bacterial inactivation of Cu2O@halloysite nanotubes hybrids with charge adsorption and physical piercing ability for medical protective fabrics)[J].材料科学技术（英文版）,2022(27):1-9

undemonstrated,Cu2+from,denatures,cherichia,steril

Ultra,fast,inactivation,Cu2O,halloysite,nanotubes,charge,adsorption,physical,piercing,ability,medical,protective,fabrics,Metals,have,been,used,wound,treatment,testing,since,ancient,times,With,develop,nanotechnology,metal,oxides,proven,excellent,sterilization,disinfection,functions,However,rapid,efficiency,trapping,physicochemical,killing,remain,simultaneously,antibacterial,nanohybrids,Here,method,situ,reduction,small,sized,particles,one,dimensional,inorganic,HNTs,resultant,only,give,dispersibility,but,also,exert,synergis,effect,Furthermore,release,damages,membranes,teins,Through,this,mechanism,allow,Es,coli,reach,within,complete,This,mode,makes,exhibit,broad,spectrum,activity,while,shows,weak,cytotoxicity,These,were,further,applied,processing,tional,fibers,Thus,believe,that,practi,cally,attractive,critical,pandemic

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