Magnesium(Mg)alloys can be regarded as the most promising biodegradable implant materials for or-thopedic and stent applications due to their good biocompatibility and low Young's modulus which is near to that of natural bone.However,its applicability is hindered because it exhibits a high corrosion rate in the physiological environments.In this work,we fabricated Mg66Zn30Ca4/Fe bulk metallic glass composites via spark plasma sintering(SPS).We studied the influence of different contents of Fe on the properties of the composites.The results indicated that Fe was uniformly distributed on the surface of Mg66Zn30Ca4 metallic glass(MG)as a second phase,which led to an improvement in the corrosion re-sistance and mechanical strength.The standard potential of Mg66Zn30Ca4/Fe bulk metallic glass(BMG)composites increased as compared to Mg66Zn30Ca4,while their mechanical strength improved from 355 MPa to 616 MPa.Furthermore,cytotoxicity was investigated via the CCK-8 assay and calcein-AM stain-ing,which revealed that the extraction mediums diluted 6 times(EM×6)of the Mg66Zn30Ca4 and Mg66Zn30Ca4/Fe did not cause cell toxicity on day 3 and 5,while the EM×6 of the Mg66Zn30Ca4 showed cytotoxicity on day 1,3 and 5.Thus,Mg66Zn30Ca4/Fe BMG composites exhibit significant potential for fabricating implants with good mechanical strength and corrosion resistance.

Kun Li;Luxin Liang;Peng Du;Zeyun Cai;Tao Xiang;Hiroyasu Kanetaka;Hong Wu;Guoqiang Xie

School of Materials Science and Engineering,Harbin Institute of Technology(Shenzhen),Shenzhen 518055,China;State Key Laboratory of Powder Metallurgy,Central South University,Changsha 410083,China;Graduate School of Biomedical Engineering,Tohoku University,Sendai,980-8579,Japan;Graduate School of Dentistry,Tohoku University,Sendai 980-8575,Japan;State Key Laboratory of Advanced Welding and Joining,Harbin Institute of Technology,Harbin 150001,China

材料科学技术（英文版）

[1]Kun Li;Luxin Liang;Peng Du;Zeyun Cai;Tao Xiang;Hiroyasu Kanetaka;Hong Wu;Guoqiang Xie-.Mechanical properties and corrosion resistance of powder metallurgical Mg-Zn-Ca/Fe bulk metal glass composites for biomedical application)[J].材料科学技术（英文版）,2022(08):73-83

thopedic,Mg66Zn30Ca4

Mechanical,properties,corrosion,resistance,powder,metallurgical,bulk,glass,composites,biomedical,Magnesium,alloys,regarded,most,promising,biodegradable,materials,stent,applications,due,their,good,biocompatibility,low,Young,modulus,which,near,that,natural,bone,However,applicability,hindered,because,exhibits,high,rate,physiological,environments,In,this,work,fabricated,metallic,via,spark,plasma,sintering,SPS,We,studied,influence,different,contents,results,indicated,was,uniformly,distributed,surface,second,phase,improvement,mechanical,strength,standard,potential,BMG,increased,compared,while,improved,from,Furthermore,cytotoxicity,investigated,CCK,assay,calcein,AM,stain,revealed,extraction,mediums,diluted,times,EM,did,not,cell,day,showed,Thus,significant,fabricating,implants

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