In regenerative medicine,a scaffold is needed to provide physical support for the growth of cells at the injury site.Carbon composites are also widely used in biomedicine.This research aimed to see if(MoWCu)S/rGO could be used in peripheral and central neural regeneration as a carbon-based nanomaterial.This material was created using a one-step hydrothermal process.We used Scanning Electron Microscopy with Energy Dispersive X-ray analysis(SEM-EDX),X-ray diffraction,and Field-Emission Scanning Electron Microscopy(FE-SEM)to describe it.The researchers used animal models of spinal cord injury and sciatic nerve injury to assess its effect as a scaffold of anti-inflammatory and electrical conductivity.The Basso Beattie Bresnahan locomotor rating scale and von Frey Filament were used to assess neuronal function after(MoWCu)S/rGO transplantation.In addition,the expression of p75 NTR and neurotrophic factors(BDNF,NT3,and NGF)mRNA in the experimental rats nerve was compared to the normal ones using Real-Time RT-qPCR.In the experimental groups,the use of(MoWCu)S/rGO resulted in a significant increase in neurotrophic factor gene expression,while p75 NTR was inversely decreased.In conclusion,we found that the nerve regeneration activity of the(MoWCu)S/rGO scaffold in rat models signifi-cantly increased motor function recovery in the treated groups.Furthermore,the current study explained the response of this composite to inflammatory neurodegenerative diseases.(MoWCu)S incorporation in graphene is thought to have excellent properties and may be used in regenerative medicine.

Nahid Askari;Mohammad Bagher Askari;Ali Shafieipour;Behnaz Salek Esfahani;Morteza Hadizadeh

Department of Biotechnology,Institute of Science and High Technology and Environmental Sciences,Graduate University of Advanced Technology,Kerman,P.O.Box 7631818356,Iran;Semiconductor Research Department,Institute of Science and High Technology and Environmental Sciences,Graduate University of Advanced Technology,Kerman,P.O.Box 7631818356,Iran;Graduated Student of Veterinary Medicine,Faculty of Veterinary Medicine,Shahid Bahonar University of Kerman,Kerman,P.O.Box 76169133,Iran;Department of Genetics and Molecular Biology,School of Medicine,Isfahan University of Medical Sciences,Isfahan,Iran;Physiology Research Center,Institute of Basic and Clinical Physiology Sciences,Kerman University of Medical Sciences,Kerman,Iran

仿生工程学报（英文版）

[1]Nahid Askari;Mohammad Bagher Askari;Ali Shafieipour;Behnaz Salek Esfahani;Morteza Hadizadeh-.The Effects of a Novel Multicomponent Transition Metal Dichalcogenide on Nervous System Regeneration)[J].仿生工程学报（英文版）,2022(05):1449-1459

Dichalcogenide,MoWCu,Filament

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