典型文献
Isolation and characterization of novel peptides from fermented products of Lactobacillus for ulcerative colitis prevention and treatment
文献摘要：
Ulcerative colitis (UC) is an incurable and highly complex digestive disease affecting millions of people worldwide. Compared to the current therapeutic drugs, bioactive peptides are more promising and safe substances as functional foods or drugs for the prevention and treatment of UC. The alcohol-soluble components from fermentation broth by fresh wheat germ and apple (AC-WGAF) were found to be effective in UC prevention in dextran sulfate sodium-induced mice in vivo. Herein, 4 novel peptides are identified from AC-WGAF by membrane ultrafiltration, recycling preparative high-performance liquid chromatography, and matrix-assisted laser desorption–ionization time-of-flight/time-of-flight mass spectrometry, possessing anti-colitis activity via using an in vitro model. One of those peptides named T24 (PVLGPVRGPFPLL) exhibited the most remarkable anti-colitis activity by preventing tight junction protein loss, maintaining epithelial barrier integrity, and promoting cell proliferation during in vitro and in vivo studies by regulating mitogen-activated protein kinase signaling pathways. Thus, T24 is a promising peptide as a functional food or novel drug for UC prevention and treatment.
文献关键词：
中图分类号：
作者姓名：
Dong He;Wen Zeng;Yi Wang;Yifan Xing;Kang Xiong;Nan Su;Chong Zhang;Yuan Lu;Xinhui Xing
作者机构：
School of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou 510006,China;Key Laboratory for Industrial Biocatalysis,Ministry of Education,Institute of Biochemical Engineering,Department of Chemical Engineering,China Center for Synthetic and Systems Biology,Tsinghua University,Beijing 100084,China;Center for Synthetic and Systems Biology,Tsinghua University,Beijing 100084,China;Institute of Biopharmaceutical and Health Engineering,Tsinghua Shenzhen International Graduate School,Shenzhen 518055,China;Institute of Biomedical Health Technology and Engineering,Shenzhen Bay Laboratory,Shenzhen 440300,China
文献出处：
引用格式：
[1]Dong He;Wen Zeng;Yi Wang;Yifan Xing;Kang Xiong;Nan Su;Chong Zhang;Yuan Lu;Xinhui Xing-.Isolation and characterization of novel peptides from fermented products of Lactobacillus for ulcerative colitis prevention and treatment)[J].食品科学与人类健康（英文）,2022(06):1464-1474
A类：
WGAF,PVLGPVRGPFPLL
B类：
Isolation,characterization,novel,peptides,from,fermented,products,Lactobacillus,ulcerative,colitis,prevention,treatment,Ulcerative,UC,incurable,highly,complex,digestive,disease,affecting,millions,people,worldwide,Compared,current,therapeutic,drugs,bioactive,more,promising,safe,substances,functional,foods,alcohol,soluble,components,fermentation,broth,by,fresh,wheat,germ,apple,AC,were,found,be,effective,dextran,sulfate,sodium,induced,mice,vivo,Herein,identified,membrane,ultrafiltration,recycling,preparative,performance,liquid,chromatography,matrix,assisted,laser,desorption,ionization,flight,mass,spectrometry,possessing,anti,activity,via,using,vitro,model,One,those,named,T24,exhibited,most,remarkable,preventing,tight,junction,protein,loss,maintaining,epithelial,barrier,integrity,promoting,cell,proliferation,during,studies,regulating,mitogen,activated,kinase,signaling,pathways,Thus
AB值：
0.641542
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
