典型文献
Gene mutation analysis and immune checkpoint therapy in head and neck squamous cell carcinoma
文献摘要：
Immune checkpoint inhibitors (ICI), represented by blocked programmed cell death-1 (PD-1), is a group of novel medicines for anti-tumor immunotherapy. It has been approved by the U.S. Food and Drug Administration (FDA) in recent years for relapsed or metastatic head and neck squamous cell carcinoma (HNSCC), and brings promising treatment prospects. However, the instability caused by tumor gene mutations significantly compromises the therapeutic effect of ICI. Therefore, the identification and analysis of HNSCC gene mutations can further guide and optimize the application of ICIs in HNSCC. In this study, we preliminarily described the clinical research progress of ICI therapy and the potential immune escape mechanism in HNSCC. An overview of complete HNSCC gene mutation results was generated from thebioinformatics study of TCGA database to further explain and analyze the relevant molecular mechanisms, which may aid in designing future personalized therapeutic strategies for HNSCC patients.
文献关键词：
中图分类号：
作者姓名：
Hua Yang;Yuxue Wei;Gangli Liu
作者机构：
Department of Stomatology,The People's Hospital of Lanling County,Lanling 277700,China;School of Stomatology,Shandong University,Shandong Provincial Key Laboratory of Oral Tissue Regeneration,Jinan 250012,China
文献出处：
引用格式：
[1]Hua Yang;Yuxue Wei;Gangli Liu-.Gene mutation analysis and immune checkpoint therapy in head and neck squamous cell carcinoma)[J].肿瘤学与转化医学（英文）,2022(01):36-42
A类：
thebioinformatics
B类：
Gene,analysis,immune,checkpoint,head,neck,squamous,cell,carcinoma,Immune,inhibitors,represented,by,blocked,programmed,death,group,novel,medicines,anti,tumor,immunotherapy,It,has,been,approved,Food,Drug,Administration,FDA,recent,years,relapsed,metastatic,HNSCC,brings,promising,treatment,prospects,However,instability,caused,mutations,significantly,compromises,therapeutic,effect,Therefore,identification,further,guide,optimize,application,ICIs,In,this,study,preliminarily,described,clinical,research,progress,potential,escape,An,overview,complete,results,was,generated,from,TCGA,database,explain,analyze,relevant,molecular,mechanisms,which,may,aid,designing,future,personalized,strategies,patients
AB值：
0.624124
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