典型文献
Phytochemicals targeting NF-κB signaling:Potential anti-cancer interventions
文献摘要：
Nuclear factor κB(NF-κB)is a ubiquitous regulator of the signalome and is indispensable for various biological cell functions.NF-κB consists of five transcription factors that execute both cytoplasmic and nuclear signaling processes in cells.NF-κB is the only signaling molecule that governs both pro-and anti-apoptotic,and pro-and anti-inflammatory responses.This is due to the canonical and non-canonical components of the NF-κB signaling pathway.Together,these pathways orchestrate cancer-related inflammation,hyperplasia,neoplasia,and metastasis.Non-canonical NF-κB pathways are particularly involved in the chemoresistance of cancer cells.In view of its pivotal role in cancer progression,NF-κB represents a potentially significant therapeutic target for modifying tumor cell behavior.Several phy-tochemicals are known to modulate NF-κB pathways through the stabilization of its inhibitor,IKB,by inhibiting phosphorylation and ubiquitination thereof.Several natural pharmacophores are known to inhibit the nuclear translocation of NF-κB and associated pro-inflammatory responses and cell survival pathways.In view of this and the high degree of specificity exhibited by various phytochemicals for the NF-κB component,we herein present an in-depth overview of these phytochemicals and discuss their mode of interaction with the NF-κB signaling pathways for controlling the fate of tumor cells for cancer-directed interventions.
文献关键词：
中图分类号：
作者姓名：
Akansha Chauhan;Asim Ul Islam;Hridayesh Prakash;Sandhya Singh
作者机构：
Amity Institute of Physiology&Allied Sciences,Amity University,Noida,Uttar Pradesh,India;Centre for Interdisciplinary Research in Basic Sciences,Jamia Millia Islamia,New Delhi,India;Amity Institute of Virology&Immunology,Amity University,Noida,Uttar Pradesh,India
文献出处：
引用格式：
[1]Akansha Chauhan;Asim Ul Islam;Hridayesh Prakash;Sandhya Singh-.Phytochemicals targeting NF-κB signaling:Potential anti-cancer interventions)[J].药物分析学报（英文）,2022(03):394-405
A类：
signalome,tochemicals
B类：
Phytochemicals,targeting,signaling,Potential,anti,cancer,interventions,Nuclear,ubiquitous,regulator,indispensable,various,biological,functions,consists,five,transcription,factors,that,execute,both,cytoplasmic,nuclear,processes,cells,only,molecule,governs,apoptotic,inflammatory,responses,This,due,canonical,components,Together,these,pathways,orchestrate,related,inflammation,hyperplasia,neoplasia,metastasis,Non,are,particularly,involved,chemoresistance,In,its,pivotal,role,progression,represents,potentially,significant,therapeutic,modifying,tumor,behavior,Several,known,modulate,through,stabilization,inhibitor,IKB,by,inhibiting,phosphorylation,ubiquitination,thereof,natural,pharmacophores,translocation,associated,survival,this,high,degree,specificity,exhibited,phytochemicals,we,herein,depth,overview,discuss,their,mode,interaction,controlling,fate,directed
AB值：
0.556706
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