典型文献
Rapid and sensitive analysis of trace β-blockers by magnetic solid-phase extraction coupled with Fourier transform ion cyclotron resonance mass spectrometry
文献摘要：
A rapid and sensitive method for analyzing trace β-blockers in complex biological samples,which involved magnetic solid-phase extraction(MSPE)coupled with Fourier transform ion cyclotron reso-nance mass spectrometry(FTICR-MS),was developed.Novel nanosilver-functionalized magnetic nano-particles with an interlayer of poly(3,4-dihydroxyphenylalanine)(polyDOPA@Ag-MNPs)were synthesized and used as MSPE adsorbents to extract trace β-blockers from biological samples.After extraction,the analytes loaded on the polyDOPA@Ag-MNPs were desorbed using an organic solvent and analyzed by FTICR-MS.The method was rapid and sensitive,with a total detection procedure of less than 10 min as well as limits of detection and quantification in the ranges of 3.5-6.8 pg/mL and 11.7-22.8 pg/mL,respectively.The accuracy of the method was also desirable,with recoveries ranging from 80.9％to 91.0％following the detection of analytes in human blood samples.All the experimental results demonstrated that the developed MSPE-FTICR-MS method was suitable for the rapid and sensitive analysis of trace β-blockers in complex biological samples.
文献关键词：
中图分类号：
作者姓名：
Xue Xiao;Kaili He;Ya-Jun Hou;Zhangmin Xiang;Yunyun Yang
作者机构：
Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology,Guangdong Provincial Engineering Research Center for Ambient Mass Spectrometry,Institute of Analysis,Guangdong Academy of Sciences(China National Analytical Center,Guangzhou),Guangzhou,510070,China
文献出处：
引用格式：
[1]Xue Xiao;Kaili He;Ya-Jun Hou;Zhangmin Xiang;Yunyun Yang-.Rapid and sensitive analysis of trace β-blockers by magnetic solid-phase extraction coupled with Fourier transform ion cyclotron resonance mass spectrometry)[J].药物分析学报（英文）,2022(02):293-300
A类：
FTICR,dihydroxyphenylalanine,polyDOPA
B类：
Rapid,sensitive,analysis,trace,blockers,by,magnetic,solid,phase,extraction,coupled,Fourier,transform,cyclotron,resonance,mass,spectrometry,rapid,method,analyzing,complex,biological,samples,which,involved,MSPE,was,developed,Novel,nanosilver,functionalized,particles,interlayer,Ag,MNPs,were,synthesized,used,adsorbents,from,After,analytes,loaded,desorbed,using,organic,solvent,analyzed,total,detection,procedure,less,than,well,limits,quantification,ranges,pg,respectively,accuracy,also,desirable,recoveries,ranging,following,human,blood,All,experimental,results,demonstrated,that,suitable
AB值：
0.443858
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