Background:Physical activity(PA)has substantial health benefits and is important in combatting chronic diseases,which have been associated with ele-vated levels of advanced glycation endproducts(AGEs).AGEs play a role in the aging process,and an association between PA and AGEs has been reported.We aimed to investigate the relationship between PA and AGE accumulation in a general population and in a population with chronic diseases.Methods:This large cross-sectional population study used data from adult participants in the LifeLines project,with participant information drawn from the LifeLines database as well data from patients with diabetes mellitus or renal and/or cardiovascular diseases.Tissue AGE accumulation was assessed non-invasively by skin-autofluorescence(SAF)using an AGE reader(DiagnOptics Technologies BV,Groningen,the Netherlands).PA was assessed using the short questionnaire to assess health-enhancing physical activity(SQUASH).Multivariate linear regression analyses were adjusted for age,body mass index,sex,and smoking status.Results:Data from 63,452 participants(general population n=59,177,chronic disease n=4275)were analyzed.The general population was signifi-cantly younger(43.58±11.77 years,mean±SD)and had significantly lower SAF(1.90±0.42 arbitrary units(AU))compared to the population with chronic disease(age:55.51±12.07 years;SAF:2.27±0.51 AU).In the group with chronic disease,more hours of moderate to vigorous physical activities per week were associated with lower SAF(β=-0.002,95％confidence interval(95％CI):-0.002 to-0.001).For the general population,there was no association between hours of moderate to vigorous activity and SAF(β=3.2×10-5,95％CI:0.000-0.001,p=0.742).However,there was an association in the general population between total hours of PA per week and SAF(β=4.2×10-4,95％CI:0.000-0.001,p＜0.001),but this association was not found in the chronic disease population(β=-3.2×10-4,95％CI:-0.001 to 0.000,p=0.347).Conclusion:Our study demonstrates that an inverse relationship exists between PA and AGE accumulation in the population with chronic disease.More hours of moderate to vigorous activity is associated with a significantly decreased SAF.More PA is associated with a lower SAF,even after adjusting for the established predictors(age,body mass index,smoking status,and sex).Our findings could help to promote health and prolong longevity.

Saskia Corine van de Zande;Jeroen Klaas de Vries;Inge van den Akker-Scheek;Johannes Zwerver;Andries Jan Smit

Department of Internal Medicine,Division of Vascular Medicine,University of Groningen,University Medical Center Groningen,Groningen,9700 RB,the Netherlands;Department of Internal Medicine,Antonius Hospital Sneek,Sneek,8601 ZK,the Netherlands;Department of Orthopaedics,University of Groningen,University Medical Center Groningen,Groningen,9700 RB,the Netherlands;Center for Human Movement Sciences,University of Groningen,University Medical Center Groningen,Groningen,9700 RB,the Netherlands;Sports Valley,Gelderse Vallei Hospital,Ede,6716 RP,the Netherlands

运动与健康科学（英文）

[1]Saskia Corine van de Zande;Jeroen Klaas de Vries;Inge van den Akker-Scheek;Johannes Zwerver;Andries Jan Smit-.A physically active lifestyle is related to a lower level of skin autofluorescence in a large population with chronic-disease(LifeLines cohort))[J].运动与健康科学（英文）,2022(02):260-265

LifeLines,combatting,endproducts,DiagnOptics,SQUASH

physically,active,lifestyle,related,lower,skin,autofluorescence,large,population,chronic,cohort,Background,Physical,activity,PA,has,substantial,health,benefits,important,diseases,which,have,been,associated,ele,vated,levels,advanced,glycation,AGEs,play,role,aging,process,association,between,reported,We,aimed,investigate,relationship,accumulation,general,Methods,This,cross,sectional,study,used,from,adult,participants,project,information,drawn,database,well,patients,diabetes,mellitus,renal,cardiovascular,Tissue,was,assessed,invasively,by,SAF,using,reader,Technologies,BV,Groningen,Netherlands,short,questionnaire,enhancing,Multivariate,linear,regression,analyses,were,adjusted,age,body,mass,sex,smoking,status,Results,Data,analyzed,younger,years,mean,had,significantly,arbitrary,units,AU,compared,In,group,more,hours,moderate,vigorous,activities,per,week,confidence,interval,For,there,However,total,but,this,not,found,Conclusion,Our,demonstrates,that,inverse,exists,More,decreased,even,after,adjusting,established,predictors,findings,could,help,promote,prolong,longevity

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