Pancreatic cancer has an overall dismal prognosis compared to most other malignancies.In general,only about 15％-20％of pa-tients are deemed upfront resectable at time of diagnosis,with a similar proportion presenting with either borderline or locally advanced disease[1].Novel and more effective treatment reg-imens including FOLFIRINOX have made yet more patients be-come resectable,with up to 60％reported in some centers[2].Technical advances in surgery continue to literally explore new anatomical territory[3].More aggressive attitude towards resec-tion of involved vessels has provided opportunity for curative at-tempt resections,even for a subpopulation of biological respon-ders staged with pre-treatment unresectable disease[4,5].How-ever,while surgery is the dominant modality for a potential cu-rative approach to pancreatic cancer,there is a subgroup of pa-tients scheduled for surgery who ends up with an aborted resec-tion during explorative laparotomy,also referred to as an"open-close laparotomy".The reasons for such non-resection events are manyfold and have likely changed over time.Indeed,in one Ital-ian study the non-resection rate remained constant at about 25％over two decades[6].While many institutional series report non-resection rates in the same range,these figures may be influenced by patient selection,referral patterns and institutional policies to-wards resection and surgical aggressiveness[2,4,6].

Kjetil S?reide

Department of Gastrointestinal Surgery,HPB Unit,Stavanger University Hospital,P.O.Box 8100,Stavanger N-4068,Norway;Department of Clinical Medicine,University of Bergen,Bergen,Norway

国际肝胆胰疾病杂志(英文版)

[1]Kjetil S?reide-.Surgical exploration with non-resection in the setting of resectable,borderline and locally advanced pancreatic cancer)[J].国际肝胆胰疾病杂志(英文版),2022(03):205-206

upfront,tempt,manyfold,Ital

Surgical,exploration,setting,borderline,locally,advanced,pancreatic,cancer,Pancreatic,has,overall,dismal,prognosis,compared,most,other,malignancies,general,only,about,deemed,diagnosis,similar,proportion,presenting,either,disease,Novel,more,effective,treatment,reg,imens,including,FOLFIRINOX,have,made,yet,patients,be,come,reported,some,centers,Technical,advances,surgery,continue,literally,explore,new,anatomical,territory,More,attitude,towards,involved,vessels,provided,opportunity,curative,resections,subpopulation,biological,respon,ders,staged,unresectable,How,ever,while,dominant,modality,potential,approach,there,subgroup,scheduled,who,ends,aborted,during,explorative,laparotomy,also,referred,open,close,reasons,such,events,likely,changed,Indeed,one,ian,study,remained,constant,two,decades,While,institutional,series,rates,same,range,these,figures,may,influenced,by,selection,referral,patterns,policies,surgical,aggressiveness

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