典型文献
A stable and reliable animal model for hepatocellular carcinoma with portal vein tumor thrombus
文献摘要：
To the Editor:
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide [ 1 , 2 ]. Portal vein tumor thrombus (PVTT) has been demonstrated to be a poor prognostic indicator for HCC [3–5] . However, effective treatment for the condition is still limited. Un- derstanding the insight into the molecular mechanisms behind PVTT development may help to establish a new therapeutic strat- egy. Animal models which mimic the development of PVTT in humans are necessary to figure out the molecular mechanisms behind PVTT development. Currently, a wide range of animal models have been established for HCC from different angles, in- cluding chemically-induced models like diethylnitrosamine, car- bon tetrachloride, thioacetamide, and phenobarbital, genetically- engineered mouse (GEM) models like Wnt/ β-catenin signaling pathway (CTNNB1), telomerase reverse transcriptase (TERT) activa- tion, aflatoxin B1 and HBV infection, and engrafted models [6–8] . However, all the above animal models cannot be used in the study of PVTT, since these models were not able to present all the histo- logical, physiological, and clinical features of human PVTT.
文献关键词：
中图分类号：
作者姓名：
Zong-Tao Chai;Zhen-Hua Chen;Xiu-Ping Zhang;Jin-Kai Feng;Zong-Han Liu;Shu-Qun Cheng
作者机构：
Department of Hepatic Surgery VI,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,225 Changhai Road,Shanghai 200433,China;Faculty of Hepato-Biliary-Pancreatic Surgery,the First Medical Center of Chinese People's Liberation Army(PLA)General Hospital,Beijing 100039,China
文献出处：
引用格式：
[1]Zong-Tao Chai;Zhen-Hua Chen;Xiu-Ping Zhang;Jin-Kai Feng;Zong-Han Liu;Shu-Qun Cheng-.A stable and reliable animal model for hepatocellular carcinoma with portal vein tumor thrombus)[J].国际肝胆胰疾病杂志(英文版),2022(01):90-93
A类：
Hepatocellular,diethylnitrosamine,phenobarbital,engrafted
B类：
stable,reliable,animal,hepatocellular,carcinoma,portal,vein,tumor,thrombus,To,Editor,HCC,one,most,common,cancers,worldwide,Portal,PVTT,has,been,demonstrated,poor,prognostic,indicator,However,effective,treatment,condition,still,limited,Un,derstanding,insight,into,molecular,mechanisms,behind,development,may,help,new,therapeutic,egy,Animal,models,which,mimic,humans,are,necessary,figure,out,Currently,range,have,established,from,different,angles,cluding,chemically,induced,like,bon,tetrachloride,thioacetamide,genetically,engineered,mouse,GEM,Wnt,catenin,signaling,pathway,CTNNB1,telomerase,reverse,transcriptase,TERT,activa,aflatoxin,HBV,infection,above,cannot,used,study,since,these,were,present,histo,physiological,clinical,features
AB值：
0.607212
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