Objective:This study aimed to analyze the relationship between cardiorespiratory fitness(CRF)and the increasing severity of coronary artery tortuosity(CAT)in patients with non-stenosed coronaries.Methods:A total of 396 patients who underwent coronary angiography and cardiopulmonary exercise testing(CPET)between August 2020 and July 2021 were included in this single-center retrospective study after excluding patients with significant coronary artery disease(≥50％stenosis).Patients were divided into two groups:no or mild coronary artery tortuosity(N/M-CAT)and moderate to severe coronary artery tortuosity(M/S-CAT)and laboratory electrocardiographic,echocardiographic,and CPET parameters were compared between two groups.Results:M/S-CAT was found in 46.9％of the study participants,with 66.7％being women.M/S-CAT was significantly associated with advanced age(P=0.014)and females(P=0.001).Diastolic dysfunction parameters,E velocity(P=0.0111),and E/A ratio(P=0.004)also revealed significant differences between the M/S-CAT group and N/M-CAT group.VO2@peak(1.22±0.39 vs.1.07±0.39,P＜0.01)and V02@AT(0.77±0.22 vs.0.71±0.21,P=0.017)were significantly lower in the M/S-CAT group than in the N/M-CAT group.Multivariate logistic regression analysis identified females(OR=0.448;95％CI,0.296-0.676;P=0.000)and E/A ratio(OR=0.307;95％CI,0.139-0.680;P=0.004)to be independent risk factors of M/S-CAT and showed no association of CPET parameters to M/S-CAT.Conclusion:The results indicate that increasing severity of CAT is strongly associated with female gender and E/A ratio and is not directly correlated with decreasing CRF.Further research with a larger patient population and a longer follow-up time is required to fully comprehend the impact of CAT on CRF.

Wan-jun LIU;Menaka DHUROMSINGH;Xing-wei HE;Yang XIE;Xiao-lei LIU;Hong-jie WANG;He-song ZENG

Department of Cardiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

当代医学科学(英文)

[1]Wan-jun LIU;Menaka DHUROMSINGH;Xing-wei HE;Yang XIE;Xiao-lei LIU;Hong-jie WANG;He-song ZENG-.Relationship between Coronary Artery Tortuosity and Cardiores-piratory Fitness in Patients without Obstructed Coronaries)[J].当代医学科学(英文),2022(05):941-948

Tortuosity,Cardiores,Obstructed,Coronaries,stenosed,coronaries

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