典型文献
Insight into Crosstalk Between Mitophagy and Apoptosis/Necroptosis:Mechanisms and Clinical Applications in Ischemic Stroke
文献摘要：
Ischemic stroke is a serious cerebrovascular disease with high morbidity and mortality.As a result of ischemia-reperfusion,a cascade of pathophysiological responses is triggered by the imbalance in metabolic supply and demand,resulting in cell loss.These cellular injuries follow various molecular mechanisms solely or in combination with this disorder.Mitochondria play a driving role in the pathophysiological processes of ischemic stroke.Once ischemic stroke occurs,damaged cells would respond to such stress through mitophagy.Mitophagy is known as a conservatively selective autophagy,contributing to the removal of excessive protein aggregates and damaged intracellular components,as well as aging mitochondria.Moderate mitophagy may exert neuroprotection against stroke.Several pathways associated with the mitochondrial network collectively contribute to recovering the homeostasis of the neurovascular unit.However,excessive mitophagy would also promote ischemia-reperfusion injury.Therefore,mitophagy is a double-edged sword,which suggests that maximizing the benefits of mitophagy is one of the direction of future efforts.This review emphasized the role of mitophagy in ischemic stroke,and highlighted the crosstalk between mitophagy and apoptosis/necroptosis.
文献关键词：
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作者姓名：
Yan-di YANG;Zi-xin LI;Xi-min HU;Hao WAN;Qi ZHANG;Rui XIAO;Kun XIONG
作者机构：
Department of Anatomy and Neurobiology,School of Basic Medical Science,Central South University,Changsha 410013,China;Clinical Medicine Eight-year Program,03 Class,18 Grade,Xiangya School of Medicine,Central South University,Changsha 410013,China;Clinical Medicine Eight-Year Program,02 Class,17 Grade,Xiangya School of Medicine,Central South University,Changsha 410013,China;Administrative Office,the Third Xiangya Hospital,Central South University,Changsha 410013,China;Hunan Key Laboratory of Ophthalmology,Changsha 410008,China;Key Laboratory of Emergency and Trauma,Ministry of Education,College of Emergency and Trauma,Hainan Medical University,Haikou 571199,China
文献出处：
引用格式：
[1]Yan-di YANG;Zi-xin LI;Xi-min HU;Hao WAN;Qi ZHANG;Rui XIAO;Kun XIONG-.Insight into Crosstalk Between Mitophagy and Apoptosis/Necroptosis:Mechanisms and Clinical Applications in Ischemic Stroke)[J].当代医学科学(英文),2022(02):237-248
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Insight,into,Crosstalk,Between,Mitophagy,Apoptosis,Necroptosis,Mechanisms,Clinical,Applications,Ischemic,Stroke,stroke,serious,cerebrovascular,disease,morbidity,mortality,ischemia,reperfusion,cascade,pathophysiological,responses,triggered,by,imbalance,metabolic,supply,demand,resulting,loss,These,injuries,follow,various,molecular,mechanisms,solely,combination,this,disorder,Mitochondria,play,driving,role,processes,ischemic,Once,occurs,damaged,cells,would,respond,such,stress,through,mitophagy,known,conservatively,selective,autophagy,contributing,removal,excessive,protein,aggregates,intracellular,components,well,aging,Moderate,may,exert,neuroprotection,against,Several,pathways,associated,mitochondrial,network,collectively,contribute,recovering,homeostasis,neurovascular,unit,However,also,promote,injury,Therefore,double,edged,sword,which,suggests,that,maximizing,benefits,direction,future,efforts,This,review,emphasized,highlighted,crosstalk,between,apoptosis,necroptosis
AB值：
0.679895
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