典型文献
Influence of Microcirculatory Dysfunction on Myocardial Injury after Cardiopulmonary Resuscitation
文献摘要：
Objective This study aimed to examine the effects of microcirculatory dysfunction and 654-1 intervention after cardiopulmonary resuscitation on myocardial injury. Methods Landrace pigs were divided into a sham operation group (S group, n = 6), ventricular fibrillation control group (VF-C group, n = 8) and 654-1 intervention group (VF-I group, n = 8). Hemodynamics was recorded at baseline, at recovery of spontaneous circulation (ROSC), and 1 h, 2 h, 4 h and 6 h thereafter. Sidestream dark field (SDF) technology was used to evaluate and monitor the microcirculation flow index, total vessel density, perfusion vessel ratio, De-Backer score, and perfusion vessel density in animal viscera at various time points. Results After administration of 654-1 at 1.5 h post-ROSC, the hemodynamics in the VF-I group, as compared with the VF-C group, was significantly improved. The visceral microcirculation detected by SDF was also significantly improved in the VF-I group. As observed through electron microscopy, significantly less myocardial tissue injury was present in the VF-I group than the VF-C group. Conclusion Administration of 654-1 inhibited excessive inflammatory by improving the state of visceral microcirculation.
文献关键词：
中图分类号：
作者姓名：
YANG Jun;DONG Gui Juan;WANG Hong Wei;ZHAO Xin;WANG Fu Jun;ZHANG Jian;GUO Shu Bin
作者机构：
Emergency Medicine Clinical Research Center of Beijing Chaoyang Hospital,Capital Medical University,Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation,Beijing 100020,China
文献出处：
引用格式：
[1]YANG Jun;DONG Gui Juan;WANG Hong Wei;ZHAO Xin;WANG Fu Jun;ZHANG Jian;GUO Shu Bin-.Influence of Microcirculatory Dysfunction on Myocardial Injury after Cardiopulmonary Resuscitation)[J].生物医学与环境科学（英文版）,2022(04):334-344
A类：
Microcirculatory,Sidestream,Backer
B类：
Influence,Dysfunction,Myocardial,Injury,Cardiopulmonary,Resuscitation,Objective,This,study,aimed,examine,effects,microcirculatory,dysfunction,intervention,cardiopulmonary,resuscitation,myocardial,injury,Methods,Landrace,pigs,were,divided,into,sham,operation,group,ventricular,fibrillation,control,VF,Hemodynamics,was,recorded,baseline,recovery,spontaneous,ROSC,thereafter,dark,field,SDF,technology,used,evaluate,monitor,microcirculation,flow,total,vessel,density,perfusion,De,score,animal,various,points,Results,After,administration,post,hemodynamics,compared,significantly,improved,visceral,detected,by,also,observed,through,electron,microscopy,less,tissue,present,than,Conclusion,Administration,inhibited,excessive,inflammatory,improving,state
AB值：
0.577169
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
