典型文献
HEXOKINASE1 forms a nuclear complex with the PRC2 subunits CURLY LEAF and SWINGER to regulate glucose signaling
文献摘要：
The glucose sensor HEXOKINASE1 (HXK1) in-tegrates myriad external and internal signals to regulate gene expression and development in Arabidopsis thaliana. However, how HXK1 me-diates glucose signaling in the nucleus remains unclear. Here, using immunoprecipitation-coupled mass spectrometry, we show that two catalytic subunits of Polycomb Repressive Complex 2, SWINGER (SWN) and CURLY LEAF (CLF), directly interact with catalytically active HXK1 and its inactive forms (HXK1G104D and HXK1S177A) via their evolutionarily conserved SANT domains. HXK1, CLF, and SWN target common glucose-responsive genes to regulate glucose signaling, as revealed by RNA se-quencing. The glucose-insensitive phenotypes of the Arabidopsis swn-1 and clf-50 mutants were similar to that of hxk1, and genetic anal-ysis revealed that CLF, SWN, and HXK1 function in the same genetic pathway. Intriguingly, HXK1 is required for CLF-and SWN-mediated histone H3 lysine 27 (H3K27me3) deposition and glucose-mediated gene repression. Moreover, CLF and SWN affect the recruitment of HXK1 to its target chromatin. These findings support a model in which HXK1 and epigenetic modifiers form a nuclear complex to cooperatively me-diate glucose signaling, thereby affecting the histone modification and expression of glucose-regulated genes in plants.
文献关键词：
中图分类号：
作者姓名：
Yutong Liu;Yunshu Bai;Ning Li;Mengting Li;Wenxin Liu;Dae-Jin Yun;Bao Liu;Zheng-Yi Xu
作者机构：
Key Laboratory of Molecular Epigenetics of the Ministry of Education(MOE),Northeast Normal University,Changchun 130024,China;Department of Biomedical Science and Engineering,Konkuk University,Seoul 132-798,South Korea
文献出处：
引用格式：
[1]Yutong Liu;Yunshu Bai;Ning Li;Mengting Li;Wenxin Liu;Dae-Jin Yun;Bao Liu;Zheng-Yi Xu-.HEXOKINASE1 forms a nuclear complex with the PRC2 subunits CURLY LEAF and SWINGER to regulate glucose signaling)[J].植物学报（英文版）,2022(06):1168-1180
A类：
HEXOKINASE1,CURLY,SWINGER,HXK1,tegrates,Repressive,SWN,HXK1G104D,HXK1S177A,swn,clf,hxk1
B类：
forms,nuclear,complex,PRC2,subunits,LEAF,glucose,signaling,sensor,myriad,external,internal,signals,expression,development,Arabidopsis,thaliana,However,diates,nucleus,remains,unclear,Here,using,immunoprecipitation,coupled,mass,spectrometry,show,that,two,Polycomb,Complex,CLF,directly,interact,catalytically,inactive,via,their,evolutionarily,conserved,SANT,domains,target,common,responsive,genes,revealed,quencing,insensitive,phenotypes,mutants,were,similar,anal,ysis,function,same,pathway,Intriguingly,required,mediated,histone,lysine,H3K27me3,deposition,repression,Moreover,recruitment,chromatin,These,findings,support,model,which,epigenetic,modifiers,cooperatively,thereby,affecting,modification,regulated,plants
AB值：
0.425697
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